Gastrointestinal drugs

Question 1

What are antacids used for?

Answer 1

Symptomatic relief of:
Gastric/duodenal ulcers
GORD
Dyspepsia

Question 2

Give an example of an antacid

Answer 2

Gaviscon

Question 3

How do H2 anatgonists work?

Answer 3

Inhibit histamine actions of all H2 receptors to inhibit gastric acid secretoins

Question 4

Example of a H2 antagonist?

Answer 4

Ranitidine

Question 5

How does Cimetidine (H2 antagonist) effect cypP450?

Answer 5

Inhibits cypP450 enzymes

Question 6

What is Omeprazole?

Answer 6

Proton pump inhibitor

Question 7

How do PPI’s work?

Answer 7

Inhibit gastric acid secretion by inhibition of proton pump of gastric parietal cells

Question 8

What drugs are metabolised by the cytochrome P450 system?

Answer 8

Warfarin
Phenytoin
Theophylline
Carbamezapine
OCP (oral contraceptive pill)

Question 9

What is loperamide?

Answer 9

Anti-diarrhoeal agent

Question 10

How does loperamide work?

Answer 10

Inhibits peristalsis

Question 11

What antidiarrhoeal should not be used in ulcerative colitis?

Answer 11

Loperamide

Question 12

Name a laxative that works by increasing peristalisis

Answer 12

Senna

Question 13

What is mesalazine used for?

Answer 13

Mild-moderate Ulcerative colitis (maintance of remission)

Question 14

What drug class is mesalazine?

Answer 14

Aminosalicylate