Neurologic Disorders

Question 1

Acute-Chronic Pain Pathophys and Pharm

Answer 1

Pathophys: abnormal prostaglandins, ion channels, 5HT, Glu, inc. sensitization in pain pathways
Pharm: inc. ENK activity, (inc. NE, 5HT), dec. PG formation

Question 2

Parkinson Disease Pathophys and Pharm

Answer 2

Pathophys: dec. striatal DA release- inc. ACh- inc. GABA inhibition
Pharm: inc. DA activity, dec. ACh activity

Question 3

Seizure Disorder Pathophys and Pharam

Answer 3

Pathophys: complex, abnormal VSSC, VSCC, dec. GABA and or inc. Glu neuronal activity
Pharm: inc. GABA activity, block VSSC, VSCC

Question 4

Alzheimer Disease Pathophys and Pharmacotherapy

Answer 4

Pathophys: dec. ACh-M, (inc. Glu excitotoxicity)
Pharm: inc. ACh activity, (dec. Glu excitotoxicity)