Embryology Flashcards

1
Q

Subventricular Zone gives rise to:

A

Neurons of the Olfactory Bulb

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2
Q

Dentate Gryus gives rise to the:

A

Hippocampus

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3
Q

External Granule Layer gives rise to:

A

Cerebellar Granule Cells

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4
Q

Sonic Hedgehog (Shh)

A

-alters dorsal-ventral patterning

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5
Q

Telencephalon

A

-becomes cerebral hemispheres

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6
Q

Diencephalon

A

-becomes thalamic structures, 3rd ventricle

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7
Q

Mesencephalon

A

-becomes midbrain, cerebral aquaduct

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8
Q

Metancephalon

A

-becomes pons and medulla

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9
Q

Myelencephalon

A

-becomes medulla

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10
Q

Rhombencephalon

A

-lumen becomes 4th ventricle

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11
Q

Homeobox (Hox)

A
  • regulate genes that code for vertebral column

- rostral-caudal patterning

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12
Q

Alar Plate

A

-forms dorsal portion of spinal cord

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13
Q

Basal Plate

A

-forms ventral portion of spinal cord

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14
Q

Sulcus Limitans

A

-separates alar and basal plates

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15
Q

Chranioraschisis

A
  • most severe neural tube defect

- failure of closure of spinal cord and skull

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16
Q

Encephalocele

A

-failure of closure of spinal cord at rostral end (neck/head)

17
Q

Myelomeningocele

A

-failure of neural tube closure at caudal end

18
Q

Sacrococcygeal Teratoma

A
  • may arise from primitive streak

- neoplasm filled with tissue on caudal end

19
Q

Chiari 1

A
  • cerebellar tonsils herniate

- associated with syringomyelia (loss of pain and temp in cape-like pattern)

20
Q

Chiari 2

A

-associated with myelomeningocele, hydrocephalus, hind brain abnormalities

21
Q

Chiari 3

A

-cervical spina bifida with cerebellar encephalocele

22
Q

Holoprosencephaly

A

-mutation in Shh gene

23
Q

Dandy Walker

A
  • inc. posterior fossa size
  • not neural tube defect- folate with not help
  • hydrocephalus
  • cystic dilation of 4th ventricle
24
Q

Lissencaphaly

A

-lack of gyri

25
Q

Schizencephaly

A

-dysplastic grey matter lined clefts