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Pharm Unit 3 > Neuroleptics > Flashcards

Neuroleptics Flashcards

1
Q

Chlorpromazine (Thorazine)

A

C: First-generation antipsychotics (phenothiazine)
M: Catalepsy (trance, muscle rigidity, lack of voluntary movement)
T: Schizophrenia (hallucinations, delusions), movement disorder in Huntingtons
SE: NMS** Extrapyramidal, tardive dyskinesia; sedation, postural hypotension, weight gain, anticholinergic effects; sexual dysfunction, hyperprolactinemia
MISC: Little effect on negative symptoms

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2
Q

Fluphenazine (Prolixin)

A

C: First-generation antipsychotics (phenothiazine)
M: Catalepsy (trance, muscle rigidity, lack of voluntary movement)
T: Schizophrenia (hallucinations, delusions), movement disorder in Huntingtons
SE: NMS** Extrapyramidal (more than chlorpromazine), tardive dyskinesia; sedation (less than chlorpromazine), hypotension, anticholinergic effects; sexual dysfunction, hyperprolactinemia
MISC: Little effect on negative symptoms

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3
Q

Trifluoperazine (Stelazine)

A

C: First-generation antipsychotics (phenothiazine)
M: Catalepsy (trance, muscle rigidity, lack of voluntary movement)
T: Schizophrenia (hallucinations, delusions)
SE: NMS** Extrapyramidal, tardive dyskinesia; sexual dysfunction, hyperprolactinemia
MISC: Little effect on negative symptoms

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4
Q

Perphenazine (Trilafon)

A

C: First-generation antipsychotics (phenothiazine)
M: Catalepsy (trance, muscle rigidity, lack of voluntary movement)
T: Schizophrenia (hallucinations, delusions)
SE: NMS** Extrapyramidal (less than chlorpromazine), tardive dyskinesia; sedation (less than chlorpromazine); sexual dysfunction, hyperprolactinemia
MISC: Little effect on negative symptoms

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5
Q

Thioridazine (Mellaril)

A

C: First-generation antipsychotics (phenothiazine)
M: Catalepsy (trance, muscle rigidity, lack of voluntary movement)
T: Schizophrenia (hallucinations, delusions)
SE: NMS** Extrapyramidal, tardive dyskinesia; sexual dysfunction, hyperprolactinemia
MISC: Little effect on negative symptoms

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6
Q

Thiothixene (Navane)

A

C: First-generation antipsychotics (thioxanthine)
M: Catalepsy (trance, muscle rigidity, lack of voluntary movement)
T: Schizophrenia (hallucinations, delusions)
SE: NMS** Extrapyramidal, tardive dyskinesia; sexual dysfunction, hyperprolactinemia
MISC: Little effect on negative symptoms

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7
Q

Loxapine (Loxitane)

A

C: First-generation antipsychotics (dibenzoxazepine)
M: Catalepsy (trance, muscle rigidity, lack of voluntary movement)
T: Schizophrenia (hallucinations, delusions)
SE: NMS** Extrapyramidal (less than chlorpromazine), tardive dyskinesia; sedation (less than chlorpromazine); sexual dysfunction, hyperprolactinemia
MISC: Little effect on negative symptoms

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8
Q

Haloperidol (Haldol)

A

C: First-generation antipsychotics (butyrophenone)
M: Catalepsy (trance, muscle rigidity, lack of voluntary movement)
T: Schizophrenia (hallucinations, delusions); severe Huntington’s movement disorders (low dose)
SE: NMS** Extrapyramidal (more than chlorpromazine), tardive dyskinesia; sedation (less than chlorpromazine), hypotension, anticholinergic effects; sexual dysfunction, hyperprolactinemia
MISC: Little effect on negative symptoms

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9
Q

Tetrabenazine (Xenazine)

A 
C: --
M: Dopamine-depleting, VMAT2 inhibitor
T: Movement disorder in Huntingtons; tardive dyskinesia
SE: NMS** 
MISC:--
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10
Q

Dantrolene (Dantrium)

A 
C:--
M: Muscle relaxant
T: Malignant hyperthermia (associated with NMS)
SE: --
MISC: --
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11
Q

Clozapine (Clozaril)

A

C: Second-Generation Antipsychotics (tricyclic)
M: D2 receptor antagonist, 5HT2 receptor antagonist
T: Treatment-resistant psychoses (including schizophrenia); decreases risk of suicide; can be used in pregnancy
SE: Agranulocytosis; weight gain, type II DM, seizure risk, hyperlipidemia** Akathesia (rare, at high doses); GI hypomotility; myocarditis
MISC: No catalepsy, no EPS, no TD

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12
Q

Olanzapine (Zyprexa)

A

C: Second-Generation Antipsychotics (tricyclic)
M: D2 receptor antagonist, 5HT2 receptor antagonist
T: Schizophrenia (effective against positive symptoms, modest effect on negative); severe bilpolar
SE: Metabolic complications (weight gain, hyperglycemia, type 2 DM, hyperlipidemia)** Somnolence, dizziness, increased serum hepatic transaminases, postural hypotension, constipation; EPS, hyperprolactinemia, akathesia may occur
MISC: –

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13
Q

Quetiapine (Seroquel)

A

C: Second-Generation Antipsychotics (tricyclic)
M: D2 receptor antagonist, 5HT2 receptor antagonist
T: Schizophrenia (effective against positive symptoms, modest effect on negative)
SE: Weight gain, hyperglycemia, postural hypotension, constipation, somnolence, dizziness**
MISC: –

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14
Q

Risperidone (Risperdal)

A

C: Second-Generation Antipsychotics (non-tricyclic)
M: D2 receptor antagonist, 5HT2 receptor antagonist
T: Schizophrenia (effective against positive symptoms, modest effect on negative); severe bilpolar
SE: Weight gain, hyperglycemia, postural hypotension, constipation, insomnia, dizziness, hyperprolactinemia; EPS at greater doses**
MISC: Fewer metabolic complications compared to tricyclics, but highest EPS in 2GA

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15
Q

Ziprazidone (Geodon)

A

C: Second-Generation Antipsychotics (non-tricyclic)
M: D2 receptor antagonist, 5HT2 receptor antagonist
T: Schizophrenia (effective against positive symptoms, modest effect on negative)
SE: Somnolence, cardiac arrhythmias (QTc prolongation); EPS in 5%**
MISC: Fewer metabolic complications compared to tricyclics

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16
Q

Paliperidone (Invega)

A

C: Second-Generation Antipsychotics (non-tricyclic)
M: D2 receptor antagonist, 5HT2 receptor antagonist; active metabolite of risperidone after P450 metabolism
T: Schizophrenia (effective against positive symptoms, modest effect on negative)
SE: Weight gain, hyperglycemia, postural hypotension, constipation, insomnia, dizziness, hyperprolactinemia; EPS at greater doses; possible QTc prolongation**
MISC: Fewer metabolic complications compared to tricyclics

17
Q

Aripiprazole (Abilify)

A

C: Second-Generation Antipsychotics (non-tricyclic)
M: Partial D2 and D3 receptor agonist, partial 5HT1a agonist, 5HT2a antagonist
T: Not as effective as other atypicals and typicals at treating schizophrenia; severe bipolar
SE: –
MISC: –

Pharm Unit 3 (14 decks)

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