Movement Disorders

Question 1

Riluzole (Rilutek)

Answer 1

C: Glutamate receptor antagonist
M: Kaninate and NDMA receptor antagonist; possibly inhibits sodium channels and G-protein coupled receptors
T: ALS
SE: Rare hepatotoxicity (check serum transaminase levels)** Nausea, diarrhea
MISC: Pertussis toxin reverses some of riluzole’s clinical effects; short improvement in median survival

Question 2

Baclofen (Lioresal)

Answer 2

C: GABAb agonist
M: Loss of spinal motor nerve inputs from cortex
T: Spasticity
SE: –
MISC: Avoid sedative-hypnotic muscle relaxants

Question 3

Tizanidine (Zanaflex)

Answer 3

C: α2 agonist
M: α2-adrenergic auto receptor agonist
T: Spasticity
SE: --
MISC:--