neuroimmunology of the eye

Question 1

limbis

Answer 1

clear to opaque

Question 2

corneal transparency decreases with

Answer 2

age
oedema
inflammation

Question 3

factors that affect transparency

Answer 3

Avascular
Non pigmented
Sensory innervation (unmyelinated b/c myelin = scattering)
Low cell density (cells have refractive index = cause scatter)
Cellular barriers and ion transport -> corneal hydration maintained

Question 4

corneal oedema

Answer 4

Reduced contrast sensitivity
Increased glare sensitivity
Halo formation

Question 5

retina immunology

Answer 5

Microglia = resident immune cell
When stressed: change in morphology (swell, bring processes in)
Location: GCL/NFL, IPL, OPL
Phagocytic clearance of pathogens, apoptotic cells, protein aggregates / debris
Also phagocytose Phr
Prune retinal synapses (& eat excessive NT)
Preferentially interact with small retinal capillaries