neuroendocrine tumor imaging with PET

Question 1

what does this include

Answer 1

GA68 labeled peptides and GA68/GE68 generators

Question 2

indications

Answer 2

-localize primary tumor and mets if present
-follow up apptmnts with known disease
-semiquanities with SUV
-select pts for SST receptor radionuclide therapy (Lu-177)

Question 3

what do NETS overexpress

Answer 3

somatostatin receptors and dotatoc goes to all 5

Question 4

SST 2=

Answer 4

somatostatin 2 overexpressed and Ga 68 dotatate binds to overexpressed in nets

Question 5

ga68 labeled peptides

Answer 5

-dotatoc (5)
-dotanoc (2,3,5)
-dotatate (2)

Question 6

normal distribution for ga68 dota

Answer 6

pituitary, thyroid, spleen, adrenals, kidneys, pancreas, prostate, liver, salivary glands

Question 7

tecnique for ga68 dota prep

Answer 7

-disconinue non radioactive somatostatin receptors 24 hrs prior to dotatate inj
-ask pt to hydrate prior

Question 8

dose mCi

Answer 8

2.7-5.4 mCi

Question 9

dose MBq

Answer 9

100-200 MBq

Question 10

how many min to waiat to image

Answer 10

45-90 minafter inj

Question 11

peak tumor uptake when

Answer 11

70+/- 20 minutes after inj

Question 12

scan where

Answer 12

upper thigh to top of head