Neurodiversity Flashcards

1
Q

What does the term neurotypical (NT) mean?

A

Individuals who are not neurodivergent

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2
Q

What does the term neurodivergent refer to?

A

Individuals who have neurological differences, opposite of neurotypical

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3
Q

What does neurodiverse mean?

A

Groups of neurodivergent people

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4
Q

What are some examples of neurodivergent conditions?

A
  • Autism Spectrum Disorder (ASD)
  • Attention Deficit Hyperactivity Disorder (ADHD)
  • Tourette Syndrome
  • Obsessive-Compulsive Disorder (OCD)
  • Bipolar Disorder
  • Dyslexia
  • Dyscalculia
  • Down Syndrome
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5
Q

What is the medical model of disability?

A

The impairment causes the disability

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6
Q

What is the social model of disability?

A

Society causes the disability due to barriers it has in place
E.g. stair vs ramp or audio only vs subtitles

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7
Q

What does ASD stand for?

A

Autism Spectrum Disorder

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8
Q

What is the definition of autism according to the National Autistic Society UK?

A

A lifelong developmental disability which affects how people communicate and interact with the world

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9
Q

What are the DSM 5 criteria for Autism Spectrum Disorder (simplified)?

A
  • Difficulties in social communication and interaction
  • Restricted and repetitive behaviours (at least two)
  • Symptoms present from an early age
  • Symptoms cause significant impairment
  • Symptoms not better explained by another disorder

May be associated with significant anxiety or depression especially in adolescents

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10
Q

What are meltdowns?

A

Outward reactions to sensory overload, often loud and can be violent

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11
Q

What are shutdowns?

A

Inward directed responses to sensory overload, characterized by quietness and withdrawal

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12
Q

What is stimming?

A

Self-stimulatory behaviour; repeated actions that vary from person to person (e.g. rocking, pacing etc)

May be a way to distract from sensory overload (stress relief)
May provide sensory input (not enough stimulus)
Just enjoyable

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13
Q

How many people are estimated to have ASD in the UK?

A

> 1 in 100

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14
Q

How many people are estimated to have ASD in the US according to the CDC (2020)?

A

1 in 36

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15
Q

What is the male-to-female diagnosis ratio for ASD?

A

Males are 4 times more likely to be diagnosed than females

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16
Q

What are some risk factors related to the aetiology of ASD?

A
  • Maternal infection during pregnancy
  • Maternal drug use during pregnancy (e.g. epilepsy medication)
  • Difficult birth
  • Older parents
  • Genetic & environmental factors (suggested by twin studies)

Also may be related to changes in amygdala function —> area that processes social interactions and fear

17
Q

What types of treatments are available for ASD?

A
  • Positive behavioural support
  • Speech and language therapy
  • Occupational therapy
  • Applied behaviour analysis (ABA) = uses rewards & punishments = criticise for trying to ‘train the autism out’ of people
  • Medications (e.g., antidepressants, anxiolytics, stimulants)
18
Q

What characterizes Attention Deficit Hyperactivity Disorder (ADHD)?

A
  • Restlessness
  • Poor concentration
  • Impulsivity

Some overlap of symptoms with ASD
ADHD & ASD are often comorbid = happen together/associated with each other (often diagnosed with both)

19
Q

What are the DSM 5 criteria for ADHD (simplified)?

A
  • Symptoms of inattention or hyperactivity/impulsivity for 6 months & there is an impact on day to day activities
  • Several symptoms present prior to age 12
  • Several symptoms present in at least two settings e.g. home & school
  • Quality of academic, social or occupational functioning is impaired
  • Symptoms not better explained by another disorder
20
Q

What is the estimated prevalence of ADHD in the UK?

A

5% of children
3.5% of adults

21
Q

What is the estimated prevalence of ADHD in the US according to the CDC (2016)?

A

7.2% of the general population; 10.2% of children
64% have at least 1 comorbid condition (depression, anxiety, autism)

Males 2x more likely to be diagnosed than females

22
Q

What are some environmental risk factors for ADHD?

A

Highly heritable (74%) BUT no ADHD gene —> lots of small genetic risk factors that add up (SERT, DAT, D4 D5 receptor, SNAP25 etc)

Environmental factors:
* Low birth weight
* Maternal smoking and alcohol use
* Brain injury
* Lead exposure

23
Q

What is Tourette Syndrome?

A

A tic disorder characterized by involuntary actions

24
Q

What are the two types of tics in Tourette Syndrome?

A
  • Motor tics = twitching, shrugging, blinking, gestures
  • Vocal tics = humming , shouting, sniffing, swearing
  • Echolalia —> repeating same thing over and over
  • Palilalia —> repeating what others say
  • Coprolalia —> swearing
25
What are the main treatment options for Tourette Syndrome?
* Behavioral approaches/coping strategies * Medication for severe cases (e.g., dopamine D2 antagonists or low dose nicotine)
26
What is the concordance rate of Tourette Syndrome in identical twins?
50-75%
27
What is the significance of Temple Grandin in relation to autism?
World's most famous autistic person; advocate for autism awareness
28
What is the importance of the quote by Temple Grandin: 'The world needs all types of minds'?
Emphasizes the value of diverse neurological perspectives
29
What is an impairment in disabilities?
A structural to functional difference in the way the body or brain works
30
What is the aetiology & neurobiology stance on ADHD?
- Overall reduction in brain volume seen in many studies - Structural changes in prefrontal cortex, striatum and others —> regions involved in attention and behavioural regulation - Reduced dopaminergic transmission in some areas - May also be issues with reduced noradrenaline levels (this can be used for treatments)
31
Treatments for ADHD
- Under 5 years = behavioural management therapy, training for parents & environmental modifications - Over 5 years = may be offered medication - Adults = environmental modifications & medications. May also use psychological interventions - Medications = Atomoxetine (NET inhibitor - non-stimulant), Methylphenidate or Dexamfetamine (DAT/NET inhibitors - stimulants), Modafinil (DAT inhibitor, effects on histamine transmission - promotes wakefulness, stimulant) NET & DAT = dopamine & noradrenaline uptake inhibitors
32
What characterises simple & complex tics?
Simple = limited number of body parts involved e.g. blinking Complex = multiple body parts, sometimes with a pattern
33
What are the DSM criteria for Tourette’s syndrome?
Multiple motor and vocal tics many times a day for at least a year Must have begun before the age of 18 Must not be due to another cause
34
What can Tourette’s syndrome be associated with?
Comorbid conditions such as ASD, depression or anxiety
35
How many people has Tourette’s syndrome?
- once thought to be very rare - now thought to be about 1% - tics usually more severe at around 10-12 years old - decline during adolescence in many people but can persist into adulthood
36
Aetiology & neurobiology of Tourette’s syndrome
- cause not understood but risk is heritable - no definitive TS associated genes - excess dopaminergic transmission - environmental factors * paternal age * difficult birth * low birth weight * maternal drug use during pregnancy