Neurodegenerative disorders Flashcards
what are neurodegenerative diseases
ensemble of conditions primarily affecting the neurons in the human brain
frequently culminate in neuronal cell death
what are neurons prone to
o2 lack- 3 mins to death (VASCULAR)
degenerative triggers
-stress
-immuno-sensitive
-toxic aggregates
-trauma
-age
POOR REGENERATIVE POWERS
when is dementia conventionally diagnosed
when progressive cognitive decline has occurs
this has had a noticeable impact upon a persons ability to carry out important everyday activities
defined according to the EXTENT of brain failure
when do the pathological changes of dementia start
likely commenced well in advance to symptoms presenting
(15-30 years)
therefore how do you reverse cell death that has already occurred
define cognition in relation to brain function
what are the 5 DOMAINS of cognition
the mental action or process of acquiring knowledge and understanding through thought, experience, and the senses
- learning and memory
- language
- visuo-spatial function
- executive function
- psychomotor abilities
what are 10 signs of dementia
poor/ decreased judgement
difficulty with simple tasks
problems communicating
misplacing things
dat-to-day forgetfulness
problems with language
difficulty solving problems
confusion of time/place
changes in personality
what is dementia
diagnosis
treatment
chronic
often global
irreversible deterioration of cognition
rule out vascular/tumour cause
but cant differentiate between different kinds of dementia
-lab and imaging
POST MORTEM ONLY DEFINITICE DIAGNOSTIC
lack reliable biomarkers
SUPPORTIVE treatment (no cure/reversing treatment)
CHOLINESTERASE INHIBITORS- temporarily improve cognition
what is dementia
diagnosis
treatment
chronic
often global
irreversible deterioration of cognition
rule out vascular/tumour cause
but cant differentiate between different kinds of dementia
-lab and imaging
POST MORTEM ONLY DEFINITICE DIAGNOSTIC
lack reliable biomarkers
SUPPORTIVE treatment (no cure/reversing treatment)
CHOLINESTERASE INHIBITORS- temporarily improve cognition
what test do you do for frontal lobe
-sequencing, verbal fluency
luria hand sequencing task
verbal fluency 1 minute words
what test do you do for temporal lobes
-memory, speech
address test
object recall
serial 7s (100-7)
what test do you do for parietal lobes
-spatial awareness (R)
-language (L)
clock face
naming objects
drawing cube, interlocking infinity
agnosia (name object with closed eye)
what screening tests are there for detecting dementia
- MINI-MENTAL STATE EXAMINATION (MMSE)
-not good at discriminating (have to be very demented) - ADDENBROOKE’S COGNITIVE EXAMINATION III
-good differentiation between dementia, MCI and controls but not dementia subtypes
what is the difference between sensitivity and specificity
AND MMSE vs ACE III
sensitivity- TRUE POSITIVE
specificity- TRUE NEGATIVE
ace has higher sensitivity and specificity
what is mild cognitive impairment
(grey zone)
cognitive impairment greater than age related impairment
decline in function of 1 or more of the 5 cognitive domains
no ADL impairment
it might progress to dementia
is alzheimers predominant in female or men
and how does it present
female
early memory disturbance
progress to dyspraxia and dysphasia
eventually immobile and mute