Neurochemistry of Memory Flashcards
list what serotonin has a role in and what undersupply can cause
Serotonin plays a part in mood, hunger, sleep and arousal
Undersupply of serotonin is linked to depression
List some things that dopamine facilitates and what under and oversupply can cause
dopamine plays a part in movement, learning, attention and emotion
undersupply is linked to parkinsons and ADHD
oversupply is linked to schizophrenia and pyschosis
List what acetylcholine facilitates and what neuropsychiatric condition it is linked to
Acetylcholine plays a part in muscle action, learning and memory
As alzheimers progresses, ACh neurones are deteriorated
List what norepinephrine facilitates and what undersupply is linked to
norepinephrine plays a part in alertness and arousal
undersupply is linked to depressed mood and ADHD
what is GABA and what is undersupply linked to
main inhibitory neurotransmitter
undersupply is linked to seizures, tremors and insomnia
What is Glutamate and what is oversupply linked to
main excitatory neurotransmitter
oversupply is linked to migraines and seizures
How is ACh formed and what receptors does it bind to
esterification of acetic acid and choline
binds to nicotinic and muscarinic channels
nicotinic are inhibited by ACh
What receptors does glutamate bind to
NMDA receptor
metabotropic receptor
AMPA receptor
How do NMDA, metabotropic and AMPA receptors act
NMDA: calcium influx, plays role in synaptic plasticity
Metabotropic: slow, secondary messengers, regulate activity in cell membranes
AMPA: rapid responders, ion channels
Give three biochemical molecules associated with alzheimers
APOE protein, Beta Amyloid plaques, Tau protein
give the three neurohistological hallmarks of alzheimers
neurofibrillary tangles, B amyloid plaques and cortical atrophy
What can be given to treat alzheimers
Acetylcholinesterase inhibitors
give examples of ACHe inhibitors
Donepazil
Pyridostigmine
Memantine
Galantamine
