Neuroblastoma and Related Tumours

Question 1

INRG staging?

Answer 1

L1 - Localized tumour not involving vital structures (without image defined risk factors (IDRFs)) and confined tot one body compartment
L2 - Locoregional tumour with presence of one or more image defined risk factor
M - distant metastatic disease (except MS)
MS - metastatic disease in children less than 18 months with disease confined to skin, liver and/or bone marrow

Question 2

Image defined risk factors?

Answer 2

• Tumour encasing major vessels in the neck/thorax/abdomen
• Encasing brachial plexus
• Extending across compartments
• Invading porta hepatis or renal pedicle
• Infiltrating organs
• Compressing spinal cord