Hemoglobinopathies Flashcards
1
Q
Structure of HbA?
A
Alpha2Beta2
2
Q
Structure of HbA2?
A
Alpha2Delta2
3
Q
Structure of HbF?
A
Alpha2Gamma2
4
Q
Structure of Hb Barts?
A
Gamma4
5
Q
Structure of HbH?
A
Beta4
6
Q
HbS: Mutation, Distribution, Clinical Significance?
A
- Beta6 glu–>val
- Africa, India, Mediterranean
- Sickle cell disease (HbSS, etc.)
7
Q
HbE: Mutation, Distribution, Clinical Significance?
A
- Beta26 glu–>lys
- Southeast Asia
- Thalassemia (HbE/Beta thal) & Sickle cell disease ( (HbSE)
8
Q
HbC: Mutation, Distribution, Clinical Significance?
A
- Beta6 glu–>lys
- Western Africa
- Hemolytic anemia (HbCC) & Sickle cell disease (HbSC)
9
Q
HbDPunjab/LA: Mutation, Distribution, Clinical Significance?
A
- Beta121 glu–>gln
- India, Pakistan, Iran
- Sickle cell disease (HbSD)
10
Q
HbOArab: Mutation, Distribution, Clinical Significance?
A
- Beta121 glu–>lys
- Africa, Middle East
- Sickle cell disease (HbSO)
