Neuroblastoma Flashcards
1
Q
Which sympathetic tissue sites?
A
70% adrenal, retroperitoneal symp chain
30% cervical/thoracic (esp infants), pelvic
2
Q
Name 3 conditions associated
A
Hirschsprungs
NF 1
BWS
3
Q
Genetic markers with poor prog
A
MYCN amplification (In 30% with advanced disease, shorter time to relapse, poor prog) Diploidy adverse Chr 1p deletion most common poor outcome
4
Q
Where does NB met to?
A
Abdo - BLASTS through midline Skin blueish subcut nodules Orbital bone proptosis, ecchymoses Vertebrae dumbbell paralysis BM Liver LUNG/CNS
5
Q
Name paraneoplastic manifestations of NB
A
Opsoclonus myoclonus "dancing eyes" "Dancing feet" HTN Secretory diarrhoea Encephalopathy
6
Q
Median age
A
2y (95%
7
Q
Markers in urine
A
Urinary VMA (end product of dopamine) HVA (end product of adrenaline/NA - 90-95%)
