Chemo For Certain Malignancies

Question 1

AML

Answer 1

Chemo more intense than ALL
INDUCTION: anthracycline and cytosine arabinoside
Dauno (anthracycline)
iT MTX
Remission ach in 80-90%
50-60% 5y surv

Therapy associated AML: alkylation agents (cyclophosphamide)
And topoisomerAse inhib (Etop) with characteristic 11q23 mutation

Question 2

ALL

Answer 2

Generally 3.5y Rx in NZ
1) induction 4 weeks 
VCR/DEX/PegAsparag
IT MTX
Dauno added if high risk

Remission status and MRD assessed at 1 month
Consolidation: Cyclophosphamide/Ara-C/thioguanine
Doxo (aim

Question 3

Germ cell tumour

Answer 3

Main: carboplat/Etop/Bleo
Option of jut carbo and Etop
Lance Armstrong: cisplat/Etop/ifos
VERY curable