Neurobiology of stress Flashcards

1
Q

What are the 2 different types of stress?

A

Eustress - positive stress that is beneficial and motivating
Distress - Negative stress, damaging and harmful that is not resolved by coping or (rapid) adaptation

Type of stressor less important than
How it is experienced
How long it goes on
Is it experienced psychologically and/or physically

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2
Q

How are the cause and the response distinguished?

A

Cause - stressor

Response - Stress response

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3
Q

What are different types of stressors?

A

Physical stressors
Psychological stress

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4
Q

What are physical stressors?

A

Processed in brainstem and hypothalamus: reflexive
Insults or injuries that produce direct physiological effects e.g. damage of body tissue and or bodily threat

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5
Q

What is psychological stress?

A

Involves PFC, amygdala, hippocampus
Stimuli that are perceived as excessively demanding or threatening, often involving antiipation

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6
Q

What are the 3 phases of stress response? (Selye’s syndrome)

A

Alarm: threat identified, body responds with state of alarm, fight or flight
Adaptation: Body engages defensive countermeasures
Exhaustion: Body runs out of defenses and resources are depleted

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7
Q

What was the proposition of allostasis?

A

How complex systems adapt (e.g. via HPA axis) to changing environments by changing set-points

Allostatic load refers to cumulative exposure to stressors and cost to the body
disagreement on whether allostasis is different from homeostasis

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8
Q

What is acute stress?

A

Brief response
to a novel but short-lived situation, experienced by the body as a danger
Conscious perception of threat is not always involved

Active stress response (fight or flight) is healthy and adaptive and necessary for survival

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9
Q

Examples of acute stress?

A

Noise
Short term fire danger
Brief physiological challenge e.g. cold or hunger
Brief illness

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10
Q

What is chronic stress?

A

Repeated ir continued exposure to threatening or dangerous situations, esp those that can’t be controlled
More likely to involve appraisal and conscious perception than acute stress

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11
Q

What are examples of chronic stress?

A

slide 11

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12
Q

What are the 5 key elements of the human stress response?

A

Biochemical
Physiological
Behavioural
Cognitive
Emotional

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13
Q

What are the 2 stress responses?

A

The autonominc nervous system: sympathomedullary pathway

The HPA axis: The pituitary- adrenal system

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14
Q

What is the sympathomedullary pathway in the stress response?

A
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15
Q

What is the HPA axis pathway?

A
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16
Q

What chemicals does the body respond to stress with?

A

Steroids - especially glucocorticoids (cortisol)
Catecholamines (adrenaline and noradrenaline)

17
Q

What is the inflammation and immune response to stress?

A

Mediated and modified by adrenaline and cortisol
Effects can be pro- and anti- inflammatory
GCCs also have direct effects on the CNS

Acute stress: immune suppression
Chronic stress: partial immune suppression + low grade chronic inflammatory response, possibly epigenetic factors

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18
Q

slide 16 to 22

A
19
Q

Which parts of the brain are key in the response to stress?

A

Amygdala
Hippocampus

20
Q

How is stress linked to physical illnesses?

A

Illnesses with strong ANS connections
Exacerbates physical illnesses, slows recovery, increases susceptibility to infection

Emerging evidence for link between chronic stress increasing ‘immune ageing’

21
Q

What is used in stress management?

A

Shiatsu, T’ai Chi, Yoga
Mindfullness
Meditation
Exercise
Sleep hygiene
Friends and family
Healthy diet
Exposure to natural environments
Aromatherapy
CBT