Neurobiology of ASD and PSD

Question 1

enhanced excitation in the immature brain allows for?

Answer 1

synaptogenesis and brain development

Question 2

critical periods

Answer 2

peak in activity-dependant plasticity and synaptogenesis

Question 3

what contributes to enhanced excitation in immature brain?

Answer 3

GABBA is excitatory
increased AMPA and NMDA

Question 4

what marks the end of critical periods?

Answer 4

increase in inhibition

Question 5

synapse and dendrite density peak at what age

Answer 5

1 years old

Question 6

glutamate receptor upregulation coincides with

Answer 6

peak in synaptic and dendritic spine density

Question 7

experience dependent plasticity driven by

Answer 7

peak plasticity and circuit adapatability during critical period

Question 8

critical period ending is marked by decreased inhibition and resultant

Answer 8

drop in experience-dependant-plasticity

Question 9

critical periods 1, 2, 3 and 4 refer to

Answer 9

somatosensory, amygdala dependant learning, hippocampal dependant learning and higher cognitive function

Question 10

Hubel and Wiesel

Answer 10

sensory deprivation impaired brain development: remained functionally blind

Question 11

psychosocial deprivation in first 5 years of life caused deficits in what domains?

Answer 11

cognitive and socio-emotional behaviours
increased pscychiatric disorder prevalence

Question 12

functional domains can be restored if adoption occured

Answer 12

before 2 years of age

Question 13

steotypies

Answer 13

repetivie behviour

Question 14

sterotypies associated with

Answer 14

psychosexual deprivation

Question 15

neural circuits underlying repetitive behaviours are

Answer 15

plastic

Question 16

ASD onset during

Answer 16

dendritic growth and branching and spine morphogenesis