Neuroanatomy and Neurochemistry of Cognition Flashcards

1
Q

What is cognition?

A

The mental action or process of acquiring knowledge and understanding through thought, experience and the senses

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2
Q

What are the functions of the frontal lobe?

A
Voluntary movement
Reasoning
Executive function
Personality
Inhibition
Initiative
Expressive language
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3
Q

What are the functions of the parietal lobe?

A
Knowing left from right
Reading/Writing
Body orientation
Calculation
Two point discrimination
Graphaethesia
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4
Q

What is Dyslexia?

A

A general term for disorders that can involve difficulty in learning to read or interpret words, letters and other symbols

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5
Q

What is Apraxia?

A

Inability to perform complex movements in the presence of normal motor, sensory and cerebellar function

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6
Q

What is Agnosia? (Tactile agnosia)

A

Inability to recognise or discriminate

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7
Q

What is Gerstmann syndrome?

A

Characterised by acalculia, agraphia, finger anomia and difficulty in differentiation of left and right

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8
Q

What are the functions of the Temporal lobe?

A
Understanding speech
Memory
Hearing
Emotions
Sense of identity
Recognising faces
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9
Q

What is the function of the Occipital lobe?

A

Primary visual reception area

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10
Q

What is Broca’s area?

A

a region in the frontal lobe of the dominant hemisphere (usually the left) of the hominid brain with functions linked to speech production.

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11
Q

What is Wernicke’s area?

A

is one of the two parts of the cerebral cortex.

It is involved in the comprehension and understanding of written and spoken language

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12
Q

What role does the Limbic System have a part in?

A

Emotional experience and Visceral regulation

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13
Q

What is the main function of the Hippocampus?

A

Memory
forming new memories
Spatial memory
Navigation

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14
Q

What is the primary structure of the limbic system comprised of?

A

Hypothalamus
Amygdala
Hippocampus and Dentate Gyrus
Cingulate gyrus

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15
Q

What is the Hypothalamus?

A

Main integrator of the autonomic and the endocrine system

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16
Q

What is the Circuit of Papez?

A

Includes;

Hippocampus, fornix, mamillary bodies, anterior thalamic nuclei, cingulate gyrus and the enterohinal cortex

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17
Q

What happens regarding the right side of the Amygdala?

A

Negative emotions

18
Q

What happens regarding the left side of the Amygdala?

A

Pleasant and unpleasant emotions

Reward system

19
Q

What are the stages of memory?

A

Encoding
Storage
Retrieval

20
Q

What is Acetylcholine?

A

An ester of acetic acid and choline

21
Q

What does Acetylcholine do?

A

Acts as a modulator

alters way other brain structures process info, rather than a chemical transferring info from point to point

22
Q

What are the 2 main classes of acetylcholine receptor?

A

Nictonic

Muscarinic

23
Q

What is glutamate?

A

Most abundant neurotransmitter

Main transmitter in the neocortex and pyramidal neurones

24
Q

What are the 3 main categories of chemical receptor for glutamate?

A

NMDA
AMPA
Metabotropic

25
Q

Is glutamate an excitatory or an inhibitory neurotransmitter?

A

Excitatory

26
Q

What needs to be present for the diagnosis of Alzheimer’s disease?

A

Insidious onset with slow deterioration
Presence of dementia
Absence of clinical evidence
Absence of a sudden apoplectic onset or of neuro signs of focal damage

27
Q

Describe Vascular dementia

A

Impairment of cognitive function is commonly uneven
Memory loss
Intellectual impairment
Focal neurological signs

28
Q

How do you diagnose vascular dementia?

A

Computerised axial tomography

Neuropathological examination

29
Q

What are associated features of vascular dementia?

A

Hypertension
Carotid bruit
Emotional lability
Transient depressive mood

30
Q

What is Lewy Body Dementia?

A

Progressive dementia with deficits in attention and executive function

31
Q

What core features are present with Lewy body dementia?

A

Fluctuating cognition with variations in attention and alertness
Recurrent complex visual hallucinations
Spontaneous features of parkinsons

32
Q

What is a suggestive feature of impending dementia or parkinsons?

A

REM sleep beahviour disorder (RBD) years earlier

33
Q

What does a PROBABLE LBD diagnosis require?

A

Dementia plus two or more core features
OR
Dementia plus one core feature and one or more suggestive features

34
Q

What does a POSSIBLE LBD diagnosis require?

A

Dementia plus one core feature

Dementia plus one or more suggestive feature

35
Q

What are supportive features of dementia? (LBD)

A
Repeated falls and syncope
Transient, unexplained loss of consciousness
Autonomic dysfunction
Hallucinations i.e. touch, hearing
Visuospatial abnormalities
Other psychiatric disturbances
36
Q

What actually is Lewy Body Dementia?

A

Neuropathology
Alpha-synuclein proteins within the cytoplasm of neurons (Lewy bodies)
Loss of dopamine in the substantia nigra
Loss of acetylcholine producing neurons

37
Q

What are the 3 types of Fronto-temporal dementia?

A

Behavioural variant frontotemporal dementia
Semantic dementia
Progressive non fluent aphasia

38
Q

What is the neuropathology of fronto-temporal dementia?

A

Pick bodies - tau +ve spherical cytoplasmic neuronal inclusions, composed of straight filaments
Pick bodies - Ballooned neurons with dissolution of chromatin)

39
Q

What is the criteria for alcohol related dementia?

A
Memory impairment +1 of:
Apraxia
Aphasia
Agnosia
Disturbance in executive function
Functional impairment
40
Q

What are 3 things caused by low thiamine levels?

A

Ophthalmoplegia
Confusion
Ataxia