Neuro-RIBS-Part1-Part2-part3 & RIBS-Spinal Anatomy-Dr. Dirks Flashcards
Neuro-RIBS-Part1
1–Central Nervous System = Brain and
Spinal Cord
2–Peripheral nervous system = cranial
and spinal NERVES
know
Neuro-RIBS-Part1
Peripheral nervous system:
2 Parts= (LOWER MOTOR NEURON)
1-• Somatic INNERVATES Skeletal muscle
2–• Autonomic INNERVATES Smooth muscle “Visceral”
(POST GANGLIONIC NEURON)
NEUROTRANSMITTORS =
1–SYMPATHETIC = __________________
2–PARASYMPATHETIC OR SKELETAL MUSCLE = __________
NOREPINEPHRIN
ACETYLCHOLINE
Neuro-RIBS-Part1
________________ involves:
– 1) Formation of a neural plate
– 2) Neural plate becomes neural groove surrounded by crests
– 3) Groove becomes closed tube in highly ordered fashion
Neurulation = “CLOSURE OF THE TUBE”
***PLATE TO GROOVE TO TUBE!!!
Neuro-RIBS-Part1
THE (((ROSTRAL))) END OF THE NEURAL TUBE DIFFERENTIATES TO FORM THE THREE “VISICLES” THAT WILL GIVE RISE TO THE ENTIRE BRAIN!!
1–PROENCEPHALON OR ____________
2–MESENCEPHALON OR____________
3–RHOMBENCEPHALON OR__________
FOREBRAIN
MIDBRAIN
HINDBRAIN
Neuro-RIBS-Part1
1–Of the 3 vesicles MES stays “MES”..NO changes!! DOES NOT DIVIDE!
2–PRO = divides into _____ &_____
3–RHOMB = _____ &__ELENCEPHALON
**WHEN THE TUBE BECOMES THE SPINAL CORD, IT IS DIVIDED INTO TWO PARTS. THAT DIVIDING PART (INTO DORSAL AND VENTRAL PART) IS CALLED THE ________ ________
*BASAL PLATE = (aka bottom) VENTRAL TO SL = MOTOR
***ALAR PLATE = DORSAL TO SL = SENSORY
TEL and DIE
MET AND MY
SULCUS LIMITANS
Neuro-RIBS-Part1
Neural crest cell fate organized by ______ level
Somite = Division of _______ in developing embryo along the neural tube.
somite
mesoderm
Neuro-RIBS-Part1
Somites include:
Dermatome
Myotome
Sclerotome
Neuro-RIBS-Part1
Parasympathetic organization
• Sacral spinal cord (mostly S2 and S3)
• Cranial Nerves:
– III: Oculomotor
– VII: Facial
– IX: Hypoglossal
– X: Vagus —–___% of all parasympathe’c control is through CN X
75%
**REMEMBER PARASYMPATHETIC ARE
3….7..9…10!!!!
Neuro-RIBS-Part1
Enteric nervous system
• Nervous system of the GI tract
• Two intramural plexuses:
__________ & ______________
• ENS is a fully functional nervous
system on its own, functions like the CNS
– There is no ________ barrier
**More neurons reside in the gut than in the spinal cord
Myenteric
submucous
blood/ENS
Neuro-RIBS-Part 1
Applicaton of the basal and alar plate rules
• Rexed Laminae
– 10
– Top 5
– Bottom 2-3
know
Neuro-RIBS-Part 1 review slide 17!
ASCENDING TRACTS:
1–DORSAL PART OF SPINAL CORD divides into ______ ________ …which divides into FASC. GRACILUS AND FASC. CUNEATUS
2–LATERAL PARTS ARE DORSAL AND VENTRAL SPINOCEREBELLAR TRACT
DESC TRACT. = LATERAL CORTICOSPINAL WILL AFFECT THE LIMBS
VENTRAL CORTICAL SPINAL WILL AFFECT THE AXIAL SKELETON
DORSAL COLUMNS
Neuro-RIBS-Part 1
Organization of motor neurons in the
spinal cord = ???
PROXIMAL MUSCLES ARE MEDIAL AND DISTAL MUSCLES ARE LATERAL OFF THE SPINAL CORD
Neuro-RIBS-Part 1
Frontal lobe = contains ________ areas
• Precentral gyrus • Superior • Middle • Inferior • Orbitofrontal cortex • Gyrus rectus • PRIMARY MOTOR CORTEX (Area\_\_\_\_\_) • PREMOTOR and SUPPLEMENTARY MOTOR CORTEX (Area 6) • BROCA’S AREA (Areas\_\_\_ \_\_\_\_ \_\_\_\_) • PREFRONTAL CORTEX (Areas 9, 10, 11, 46) • Frontal eye fields (Area 8)
motor
4
44, 45, 47)
Neuro-RIBS-Part 1
Parietal lobe contains ____________
areas
• Postcentral gyrus • Superior lobule • Inferior lobule – Supramarginal gyrus – Angular gyrus • Precuneus • Primary somatosensory cortex (Areas\_\_\_ \_\_\_\_ \_\_\_) • \_\_\_\_\_ \_\_\_\_\_ (around border with temp., frontal) • Spatial orientation and perception
somatosensory
1,2,3
Language comprehension
Neuro-RIBS-Part 1
Temporal lobe contains _____ areas
- Superior
- Middle
- Inferior
- Fusiform
- Primary auditory cortex (Areas___ _____)
- Wernicke’s Area (Area 22)
- Ventral stream of “_____”
- Learning and ________
auditory
41, 42
what?
Memory
Neuro-RIBS-Part 1
Occipital lobe contains ______ areas
• Cuneus – V1 (primary visual cortex) – Area \_\_\_\_ • V2 (visual association cortex) – Area \_\_\_\_ • Calcarine sulcus • Occipital pole =\_\_\_\_\_\_\_\_
visual
17
18
fovea
Neuro-RIBS-Part 1
Limbic lobe involves _______ and
______
• __________ gyrus
• Parahippocampal gyrus
memory
emotion
Cingulate
Neuro-RIBS-Part 1 - Association and commissural fibers
1) ______ Fibers = pass from one part of a SINGLE hemisphere to another
2) ________ Fibers = Link matching areas of the two hemispheres
3) ________ Fibers = Run to subcoritcal nuclei
Association
Commissural
Projection
Neuro-RIBS-Part 1
What is the developmental fate of neurons in
the alar plate?
The alar plate specifically later on becomes the dorsal gray of the spinal cord, and develops into the SENSORY nuclei of cranial nerves V, VII, VIII, IX, and X.
Neuro-RIBS-Part 1
What is the developmental fate of the metencephalon?
PONS AND CEREBELLUM
Neuro-RIBS-Part 1
What type of fibers make up the corpus callosum?
COMMISURAL
Neuro-RIBS-Part 1
What function is associated with Broadmann’s
Area 1?
PRIMARY SOMATOSENSORY CORTEX
Neuro-RIBS-Part 1
What are the major cell type in Rexed Lamina
VIII?
LOWER MOTOR NEURON
Neuro-RIBS-Part 1
What kind of information is carried in the
white ramus communicans?
WHITE RAMUS = T1–L2
GRAY RAMUS = THE WHOLE THING!
PRE-GANGLIONIC SYMPATHETIC
FYI***GRAY RAMUS IS POST-GANGLIONIC SYMPATHETIC
Neuro-RIBS-Part 1 —-last NEURO OF PART 1
What kind of information, sensory or motor, is
carried in the dorsal ramus of a spinal nerve?
BOTH
Neuro-RIBS-Part 2
Ipsilaterality and contralaterality
• Cortex is _________ to spinal cord signal
• Cortex and _____ are on the same side
• Basal ganglia and cortex are on the same side
• _____and spinal cord are usually on the same side
– So cerebellum is collateral to _____
• Think pontine nuclei
contralateral
thalamus
Cerebellum
cortex
Neuro-RIBS-Part 2
Right Side = Cortex…Thalamus..Basal Ganglia
Left Side = Spinal Cord…Cerebellum….Sensory Input….
……Motor Output
know
Neuro-RIBS-Part 2
Descending control of Pain
- ALL points along this pathway are sensitive to ________ and enkephalins
- Bilateral
endorphins
Neuro-RIBS-Part 2
Gamma Motor neurons alter ______ sensitivity
• Intrafusal fibers have minor role in contraction
• But innervated by Gamma motor neurons
– Purpose is to always keep the spindle _______ to a certain extent to signal status
spindle
stretched
Neuro-RIBS-Part 2-
-Dorsal Columns
– Name of pathway – Type of information in pathway – Point of origin, receptors involved – Where primary cell bodies are located – Where 1st synapse is – Where in Spinal Cord it enters, travels – Where/if it decussates – Where second synapse is – Final destination
The posterior column (dorsal column) refers to the area of white matter in the middle to posterior side of the spinal cord. It is made up of the gracile fasciculus and the cuneate fasciculus and itself is part of the posterior funiculus. It is part of an ascending pathway that is important for well-localized fine touch and conscious proprioception called the posterior column-medial lemniscus pathway.
Joint capsules, tactile and pressure receptors send a signal through the posterior root ganglia up through the gracile fasciculus for lower body sensory impulses and the cuneate fasciculus for upper body impulses. Once the gracile fasciculus reaches the gracile nucleus, and the cuneate fasciculus reaches the cuneate nucleus in the lower medulla oblongata, they begin to cross over as the internal arcuate fibers. Upon reaching the opposite side, they become the medial lemniscus, which is the second part of the posterior column-medial lemniscus pathway.
Neuro-RIBS-Part 2
Neospinothalamic – Name of pathway – Type of information in pathway – Point of origin, receptors involved – Where primary cell bodies are located – Where 1st synapse is – Where in Spinal Cord it enters, travels – Where/if it decussates – Where second synapse is – Final destination
The neospinothalamic tract has few synapses and constitutes the classical lateral spinothalamic tract (LST) (Figure 7.1). The first-order nociceptive neurons (in the DRG) make synaptic connections in Rexed layer I neurons (marginal zone). Axons from layer I neurons decussate in the anterior white commissure, at approximately the same level they enter the cord, and ascend in the contralateral anterolateral quadrant. Most of the pain fibers from the lower extremity and the body below the neck terminate in the ventroposterolateral (VPL) nucleus and ventroposteroinferior (VPI) nucleus of the thalamus, which serves as a relay station that sends the signals to the primary cortex. The VPL is thought to mainly be concerned with discriminatory functions. The VPL sends axons to the primary somatosensory cortex (SCI).
Neuro-RIBS-Part 2
Poorly localized pain in other pathways:
• C-fibers • Polymodal receptors • Terminate in Brainstem, midbrain, hypothalmus • Called \_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_ and/or Archespinothalmic tracts • Slow • \_\_\_\_\_\_\_\_\_-related
Paleospinothalmic
Emotion
Neuro-RIBS-Part 2
***MOSSY FIBERS–in CEREBELLUM via spinal cerebellum path.
**CLIMBING FIBER–originate in INFERIOR OLIVARY NUCLEUS
***GRANULE CELLS»_space;PARALLEL FIBERS SYAPSE ON PURKINJE CELLS AND THEN SEND TO DEEP CEREBELLAR NUCEI (DCN)
Sensory components of CN V
1–Main sensory – _________ discrimination
2–Spinal trigeminal – Light touch, pain, temperature
3– Mesencephalic – Proprioceptive
Vibrotactile
Neuro-RIBS-Part 2
Medial longitudinal fasciculus (MLF) a mixed pathway carried by the VESTIBULAR NERVE
***involves the __________ ABDUCENS AND THE
___________ OCCULOMOTOR NUCLEUS
Head moves right…eyes move left.
CONTRALATERAL
IPSILATERAL
Neuro-RIBS-Part 2
Pyramidal Tract
Decussates (Mostly)
– 80% CROSSING OVER at caudal medulla
= “_______ corticospinal tract”
• Limbs, digits (stuff needing fine motor control)
– 20% continue ipsilateral DOES NOT CROSS OVER
• “________ or ventral corticospinal tract”
• Axial muscles
• Some of these will decussate some won’t
• These travel until thoracic spinal cord
Lateral
anterior
Neuro-RIBS-Part 2
Upper motor neuron control of lower motor neurons
A---• 4 brainstem pathways: related to posture: “\_\_\_\_\_\_\_\_\_\_\_\_\_” 1– Vestibular (vestibulospinal) 2– Reticular (reticulospinal) 3– Red nucleus (rubrospinal) 4– Superior colliculus (tectospinal)
B–• 2 cortical pathways: related to limbs, facial muscles
1– Direct
2– Indirect
(via first synapsing in the brainstem—”__________”)
extrapyramidal
corticobulbar
Neuro-RIBS-Part 2
Typical signs of LOWER motor neuron damage
1--• Paralysis or paresis 2--• AREFLEXIA – Loss of muscle tone (related to areflexia) 3--• \_\_\_\_\_\_\_\_\_\_\_ – Due to denervation and disuse 4- • Twitching
Atrophy
Neuro-RIBS-Part 2
UPPER motor neuron damage
1–• _________ ________
– Toes point upward instead of downward due to loss of Upper motor neuron control
2–• Spasticity
– ___________ influences probably are somewhat inhibitory to the brainstem control of postural muscles—relaxes them a bit.
3–• Loss of fine motor control
– Due to corticospinal damage
Babinski’s sign
Corticospinal
Neuro-RIBS-Part 2
Where is the first synapse for ascending pain info of the face?
Which thalamic nucleus receives tactile information from hands and feet?
SPINAL TRIGEMINAL NUCLEUS
THE VPL
Neuro-RIBS-Part 2
Which pathway controls the vestibulo-ocular reflex?
What cerebellar pathway(s) carry unconscious prorpioceptive info about the upper half of the body?
THE MLF
THE CUNEAL ROSTRAL CEREBELLAR
Neuro-RIBS-Part 2
Paleospinothalmic pain information is carried ipsilaterally, bilaterally or contralaterally through the spinal cord?
BILATERAL
Neuro-RIBS-Part 2—last one
What are some examples of extrapyramidal pathways?
1–TECTO
2–VESTIBULO
3–RETICULO
Neuro-RIBS-Part 3
The neuroendocrine hypothalamus
1–• Nuclei involved in release of hormones through the hypophysis
2–• Neurohypophysis (_______ pituitary)
– Direct neuroendocrine release
3–• Adenohypophysis (________ pituitary)
– Release via a vascular link within the ant. pituitary
posterior
anterior. A = A tip
Neuro-RIBS-Part 3
Neurohypophysis
1–• 2 hypothalamic nuclei: supraoptic and paraventricular
– Magnocellular
2–• ______ (vasopressin)
– Water reabsorption
3–• ________ = Milk letdown reflex, uterine contractions
ADH
Oxytocin
Neuro-RIBS-Part 3
Signaling molecules through adenohypophesis
Releasing Hormone CRH TRH GHRH GnRH Dopamine
Anterior Lobe Hormone ACTH Thyrotropin Growth hormone FSH/LH Prolactin
Parvocellular neurons release the “__________ hormones”
releasing
Neuro-RIBS-Part 3
What’s the limbic system again?
• Base of the ________—sits on top of ___________ structures…named ajer boundary or borders
cortex
subcortical