Neuro/Psych

Question 0

Dose of amitriptyline

Answer 0

Depression: 75-200mg in divided or pre-bedtime doses
Neuropathic pain: 10mg at night
Migraine prophylaxis: 10mg at night (may be increased)

Question 1

Dose of citalopram

Answer 1

PO 20mg OD up to 40mg OD

Question 2

Dose of zopiclone

Answer 2

3.75-7.5mg nocte

Question 3

Mechanism of action of quetiapine

Answer 3

Short acting atypical antipsychotic.

Dopamine, serotonin and adrenergic antagonist, potent antihistamine

Question 4

Dose of quetiapine

Answer 4

Schizophrenia: Max 750mg in divided doses. Usual range 300-450mg
Mania: max 800mg in divided doses. Usual range 400-800mg
BP Depression: max 600mg in divided doses. Usual dose 300mg

Question 5

Mechanism of action of olanzapine

Answer 5

Atypical antipsychotic. High affinity for serotonin and dopamine (less for latter). Potent antagonist for M3

Question 6

Dose of olanzapine

Answer 6

PO: 5-20mg
Rapid control IM: 10mg, 5mg in elderly. Repeat after 2hrs if necessary
Deep IM: 210-300mg every 2 weeks then maintenance dose lower but adjusted to response

Question 7

Dose of venlafaxine

Answer 7

75mg/day. Max 375mg/day

Question 8

Dose of mirtazapine

Answer 8

15-30mg nocte up to 45mg

Question 9

Dose of Haloperidol

Answer 9

PO: maintenance 1-3mg/day, max 20mg

Deep IM: 50mg/4wk up to 300mg/4wk

Question 10

Dose of chlorpromazine

Answer 10

PO: max 300mg/day, start 25mg TDS

Deep IM: 25-50mg/6-8h

Question 11

Dose of gabapentin

Answer 11

Initially 300mg OD, usual dose 0.9-3.6g/day in 3 doses. Max 4.8/day.

Question 12

Dose of sodium valproate

Answer 12

PO: 1-2g/day, max 2.5g
IV: 10mg/kg, max 2.5g

Question 13

Dose of phenytoin

Answer 13

Initial dose: 20mg/kg (max 2g) slow IV

Maintenance: 100mg PO/IV /6-8h