Neuro-pharmacology: MS/stroke/headache Flashcards
Three broad categories of MS drug delivery
injectable, oral, infusions
3 injectables
interferon 1b and 1a (neutralizing abs form), glatiramer acetate (safe in pregnancy)
3 orals
dimethyl fumurate (tecFIDera), Fingolimod (Gilenya), Teriflunomide (aubagio, category x in pregnancy)
4 infusions
natalizumab (tysabri), alemtuzumab (lemtrada), ocrelizumbad (ocrevus),
dalfampridine (ampyra)
Name the MS drug: increase risk of seizure, improves ambulation
dalfampridine (ampyra)
Name the MS drug: CD52 binder, check thyroid, kidney and platelets
alemtuzumab (lemtrada)
Name the MS drug: anti CD 20 , fancy rituximab
ocrevus (ocrelizumab)
Name the MS drug: highest risk of JC/PML, blocks t-cells from crossing BBB
natalizumab (tysabri)
Name the MS drug: contraindicated in pregnancy (2 years prior to conception) and cirrhosis, alopecia
Teriflunimide (aubagio)
Name the MS drug: inhibitos DHODH (dihydroorotate dehydrogenase)
Teriflunimide (aubagio)
Name the MS drug: first dose observation for bradycardia, inhibiits S1P receptors (sphingosine-1-phosphate) which sequesters T-cells in lymphocytes
fingolimod (gilenya)