Neuro-pharmacology: MS/stroke/headache Flashcards

1
Q

Three broad categories of MS drug delivery

A

injectable, oral, infusions

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2
Q

3 injectables

A

interferon 1b and 1a (neutralizing abs form), glatiramer acetate (safe in pregnancy)

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3
Q

3 orals

A

dimethyl fumurate (tecFIDera), Fingolimod (Gilenya), Teriflunomide (aubagio, category x in pregnancy)

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4
Q

4 infusions

A

natalizumab (tysabri), alemtuzumab (lemtrada), ocrelizumbad (ocrevus),
dalfampridine (ampyra)

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5
Q

Name the MS drug: increase risk of seizure, improves ambulation

A

dalfampridine (ampyra)

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6
Q

Name the MS drug: CD52 binder, check thyroid, kidney and platelets

A

alemtuzumab (lemtrada)

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7
Q

Name the MS drug: anti CD 20 , fancy rituximab

A

ocrevus (ocrelizumab)

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8
Q

Name the MS drug: highest risk of JC/PML, blocks t-cells from crossing BBB

A

natalizumab (tysabri)

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9
Q

Name the MS drug: contraindicated in pregnancy (2 years prior to conception) and cirrhosis, alopecia

A

Teriflunimide (aubagio)

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10
Q

Name the MS drug: inhibitos DHODH (dihydroorotate dehydrogenase)

A

Teriflunimide (aubagio)

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11
Q

Name the MS drug: first dose observation for bradycardia, inhibiits S1P receptors (sphingosine-1-phosphate) which sequesters T-cells in lymphocytes

A

fingolimod (gilenya)

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