Neuro-pharmacology - basics

Question 1

Define pharmacokinetics

Answer 1

how drugs move and are modified (dose-concentration relationship)

Question 2

what are the four fundamentals of pharmacokinetics

Answer 2

absorption, distribution metabolism and excretion

Question 3

define pharmacodynamics

Answer 3

drug and its biochemical and physiologic effects (concentration - effect)

Question 4

what GI issue can lead to sub-therapeutic phenytoin levels ?

Answer 4

antacids/low pH in the stomach

Question 5

Three things that effect volume of distribution

Answer 5

lipid solubility
total body mass
percentage of body fat

Question 6

does a protein bound medication have a pharmacodynamic effect ?

Answer 6

No

Question 7

what type of molecules easily cross the BBB ?

Answer 7

lipid soluble (hydrophilic have difficulty)

Question 8

how does drug inactivation occur ?

Answer 8

cytochrome p450 enzyme pathways and conjugation

Question 9

Name 5 commonly prescribed p450 INHIBITORS

Answer 9

Diltiazem, Amiodarone, Metronidazole, FLUoxetine, verapamil

Question 10

PHT, PHb, TPM and CBZ are all P450 ____rs.

Answer 10

inducers (TPM >200mg/d)

Question 11

p450 enzyme that effects response to clopidogrel

Answer 11

CYP2C19

Question 12

Pts of asian descent starting on CBZ should be screened for this HLA allele.

Answer 12

HLA-B*1502