Neuro Pharm (Konorev)

Question 1

Phenylephrine (Neo-Synephrine)

Answer 1

Gq
alpha1 agonist
direct adrenomimetic

Question 2

Prazosin

Answer 2

Gq
alpha1 antagonist
alpha2-B antagonist
alpha2-C antagonist

Question 3

Tamsulosin

Answer 3

alpha1-A antagonist

Gq

Question 4

Clonidine (Catapres)

Answer 4

Gi
alpha2 agonist
direct adrenomimetic

Question 5

Yohimbine

Answer 5

Gi

alpha2 antagonist

Question 6

Oxymetazoline

Answer 6

Gi

alpha2-A agonist

Question 7

Isoproterenol (Isuprel)

Answer 7

Gs
Beta-agonist
direct adrenomimetic

Question 8

Propranolol

Answer 8

Gs

Beta antagonist

Question 9

Dobutamine (Dobutrex)

Answer 9

Gs
Beta1 agonist
direct adrenomimetic

Question 10

Albuterol (Ventolin)

Answer 10

Gs
Beta2 agonist
direct adrenomimetic

Question 11

Mirabegron

Answer 11

Gs

Beta3 agonist

Question 12

Betaxolol

Answer 12

Gs

Beta1 antagonist

Question 13

Butoxamine

Answer 13

Gs

Beta2 antagonist

Question 14

Fenoldopam (Corlopam)

Answer 14

Gs
D1 agonist
direct adrenomimetic

Question 15

Bromocriptine

Answer 15

Gi

D2 agonist

Question 16

Clozapine

Answer 16

Gi

D4 antagonist

Question 17

Tissue - Vascular smooth muscle
Action - contraction
Receptor type - ?

Answer 17

alpha1

Question 18

Tissue - Pupil dilation muscle
Action - contraction (dilation)
Receptor Type - ?

Answer 18

alpha1

Question 19

Tissue - Pilomotor smooth muscle
Action - Erects hair
Receptor Type - ?

Answer 19

alpha1

Question 20

Tissue - Prostate
Action - Contraction
Receptor Type - ?

Answer 20

alpha1

Question 21

Tissue - Heart
Action - increases force of contraction
Receptor Type - ?

Answer 21

alpha1

Question 22

Tissue - postsynaptic CNS neurons
Action - probably multiple…
Receptor Type - ?

Answer 22

alpha2

Question 23

Tissue - platelet
Action - aggregation
Receptor Type - ?

Answer 23

alpha2

Question 24

Tissue - adrenergic and cholinergic nerve terminals
Action - inhibits transmitter release
Receptor Type - ?

Answer 24

alpha2

Question 25

Tissue - some vascular smooth muscle Action - contraction Receptor Type - ?

Answer 25

alpha2

Question 26

Tissue - fat cells Action - inhibits lipolysis Receptor Type - ?

Answer 26

alpha2

Question 27

Tissue - hear, juxtaglomerular cells Action - increase force and rate of contraction; increases renin release Receptor Type - ?

Answer 27

beta1

Question 28

Tissue - respiratory, uterine, and vascular smooth muscle Action - promotes smooth muscle relaxation Receptor Type - ?

Answer 28

beta2

Question 29

Tissue - skeletal muscle Action - promotes potassium uptake Receptor Type - ?

Answer 29

beta2

Question 30

Tissue - human liver Action - activates glycogenolysis Receptor Type - ?

Answer 30

beta2

Question 31

Tissue - bladder Action - relaxes detrusor muscle Receptor Type - ?

Answer 31

beta3

Question 32

Tissue - fat cells Action - activates lipolysis Receptor Type - ?

Answer 32

beta3

Question 33

Tissue - smooth muscle Action - dilates renal blood vessels Receptor Type - ?

Answer 33

D1

Question 34

Tissue - nerve endings Action - modulates transmitter release Receptor Type - ?

Answer 34

D2

Question 35

Gq agonist

Answer 35

increase IP3, DAG common to all

Question 36

Gi agonist

Answer 36

decrease cAMP common to all

Question 37

Gs agonist

Answer 37

increase cAMP common to all

Question 38

Methoxamine (vasoxyl)

Answer 38

direct adrenomimetic | alpha agonist

Question 39

Mixed alpha and beta agonists

Answer 39

Norepinephrine (Levophed) | Epinephrine (Adrenalin)

Question 40

Terbutaline (Brethine)

Answer 40

Beta agonist | direct adrenomimetic

Question 41

Dopamine (Intropin)

Answer 41

Dopamine agonist | direct adrenomimetic

Question 42

tachyphylaxis

Answer 42

Acute decrease in response to drug after its administration.

Question 43

Epi effects on cardiac function (Beta1)

Answer 43

Increase: force of contraction, heart rate, AVnode conduction velocity

Question 44

Epi effects on vascular tone (Beta2 and Alpha1)

Answer 44

Increase systolic BP Decrease diastolic BP and total peripheral vascular resistance MAP unchanged

Question 45

receptor type found in vascular beds of: | skin vessels and mucous membranes

Answer 45

mostly alpha1

Question 46

receptor type found in vascular beds of: | skeletal muscle

Answer 46

alpha1 and beta2

Question 47

receptor type found in vascular beds of: | renal, cerebral

Answer 47

D1 and alpha1

Question 48

Epi effects on respiratory system (a1=a2; B1=B2)

Answer 48

B2 - relax bronchial m | A1 - decrease bronchial secretion and congestion within bronchial mucosa

Question 49

Epi effects on skeletal muscle (B2)

Answer 49

B2 - muscle tremor | B2 - increases K+ uptake

Question 50

Epi effects on blood glucose levels (B2, a2)

Answer 50

B2 - enhance liver glyconenolysis | A2 and B2 - inhibitis insulin release

Question 51

Epi effect on free fatty acid levels in blood (B)

Answer 51

increases

Question 52

Epi effect on renin (B1)

Answer 52

increase release

Question 53

NE (a1=a2; B1 >> B2)

Answer 53

Cardiac stimulant, but REDUCES HR Vasoconstrictor = increase BP Increase peripheral vascular resistance and BP

Question 54

Affinity of NE toward B2

Answer 54

LOW = large increase in BP

Question 55

Dopamine (D1=D2 >> B1 >> a1)

Answer 55

D1 = vasodilation (