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Neuro II > Neuro Pharm (Konorev) > Flashcards

Neuro Pharm (Konorev) Flashcards

1
Q

Phenylephrine (Neo-Synephrine)

A

Gq
alpha1 agonist
direct adrenomimetic

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2
Q

Prazosin

A

Gq
alpha1 antagonist
alpha2-B antagonist
alpha2-C antagonist

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3
Q

Tamsulosin

A

alpha1-A antagonist

Gq

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4
Q

Clonidine (Catapres)

A

Gi
alpha2 agonist
direct adrenomimetic

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5
Q

Yohimbine

A

Gi

alpha2 antagonist

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6
Q

Oxymetazoline

A

Gi

alpha2-A agonist

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7
Q

Isoproterenol (Isuprel)

A

Gs
Beta-agonist
direct adrenomimetic

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8
Q

Propranolol

A

Gs

Beta antagonist

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9
Q

Dobutamine (Dobutrex)

A

Gs
Beta1 agonist
direct adrenomimetic

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10
Q

Albuterol (Ventolin)

A

Gs
Beta2 agonist
direct adrenomimetic

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11
Q

Mirabegron

A

Gs

Beta3 agonist

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12
Q

Betaxolol

A

Gs

Beta1 antagonist

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13
Q

Butoxamine

A

Gs

Beta2 antagonist

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14
Q

Fenoldopam (Corlopam)

A

Gs
D1 agonist
direct adrenomimetic

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15
Q

Bromocriptine

A

Gi

D2 agonist

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16
Q

Clozapine

A

Gi

D4 antagonist

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17
Q

Tissue - Vascular smooth muscle
Action - contraction
Receptor type - ?

A

alpha1

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18
Q

Tissue - Pupil dilation muscle
Action - contraction (dilation)
Receptor Type - ?

A

alpha1

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19
Q

Tissue - Pilomotor smooth muscle
Action - Erects hair
Receptor Type - ?

A

alpha1

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20
Q

Tissue - Prostate
Action - Contraction
Receptor Type - ?

A

alpha1

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21
Q

Tissue - Heart
Action - increases force of contraction
Receptor Type - ?

A

alpha1

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22
Q

Tissue - postsynaptic CNS neurons
Action - probably multiple…
Receptor Type - ?

A

alpha2

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23
Q

Tissue - platelet
Action - aggregation
Receptor Type - ?

24
Q

Tissue - adrenergic and cholinergic nerve terminals
Action - inhibits transmitter release
Receptor Type - ?

25
Q

Tissue - some vascular smooth muscle
Action - contraction
Receptor Type - ?

26
Q

Tissue - fat cells
Action - inhibits lipolysis
Receptor Type - ?

27
Q

Tissue - hear, juxtaglomerular cells
Action - increase force and rate of contraction; increases renin release
Receptor Type - ?

28
Q

Tissue - respiratory, uterine, and vascular smooth muscle
Action - promotes smooth muscle relaxation
Receptor Type - ?

29
Q

Tissue - skeletal muscle
Action - promotes potassium uptake
Receptor Type - ?

30
Q

Tissue - human liver
Action - activates glycogenolysis
Receptor Type - ?

31
Q

Tissue - bladder
Action - relaxes detrusor muscle
Receptor Type - ?

32
Q

Tissue - fat cells
Action - activates lipolysis
Receptor Type - ?

33
Q

Tissue - smooth muscle
Action - dilates renal blood vessels
Receptor Type - ?

34
Q

Tissue - nerve endings
Action - modulates transmitter release
Receptor Type - ?

35
Q

Gq agonist

A

increase IP3, DAG common to all

36
Q

Gi agonist

A

decrease cAMP common to all

37
Q

Gs agonist

A

increase cAMP common to all

38
Q

Methoxamine (vasoxyl)

A

direct adrenomimetic

alpha agonist

39
Q

Mixed alpha and beta agonists

A

Norepinephrine (Levophed)

Epinephrine (Adrenalin)

40
Q

Terbutaline (Brethine)

A

Beta agonist

direct adrenomimetic

41
Q

Dopamine (Intropin)

A

Dopamine agonist

direct adrenomimetic

42
Q

tachyphylaxis

A

Acute decrease in response to drug after its administration.

43
Q

Epi effects on cardiac function (Beta1)

A

Increase: force of contraction, heart rate, AVnode conduction velocity

44
Q

Epi effects on vascular tone (Beta2 and Alpha1)

A

Increase systolic BP
Decrease diastolic BP and total peripheral vascular resistance
MAP unchanged

45
Q

receptor type found in vascular beds of:

skin vessels and mucous membranes

A

mostly alpha1

46
Q

receptor type found in vascular beds of:

skeletal muscle

A

alpha1 and beta2

47
Q

receptor type found in vascular beds of:

renal, cerebral

A

D1 and alpha1

48
Q

Epi effects on respiratory system (a1=a2; B1=B2)

A

B2 - relax bronchial m

A1 - decrease bronchial secretion and congestion within bronchial mucosa

49
Q

Epi effects on skeletal muscle (B2)

A

B2 - muscle tremor

B2 - increases K+ uptake

50
Q

Epi effects on blood glucose levels (B2, a2)

A

B2 - enhance liver glyconenolysis

A2 and B2 - inhibitis insulin release

51
Q

Epi effect on free fatty acid levels in blood (B)

52
Q

Epi effect on renin (B1)

A

increase release

53
Q

NE (a1=a2; B1&raquo_space; B2)

A

Cardiac stimulant, but REDUCES HR
Vasoconstrictor = increase BP
Increase peripheral vascular resistance and BP

54
Q

Affinity of NE toward B2

A

LOW = large increase in BP

55
Q

Dopamine (D1=D2&raquo_space; B1&raquo_space; a1)

A

D1 = vasodilation (

Neuro II (9 decks)

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