Neuro-oncology Flashcards
Child with cerebellar cyst associated with mural nodule
Adult with cerebellar cyst associated with mural nodule
Child–Juvenile pilocytic astrocytoma
Adult–hemangioblastoma and Von Hippel-Lindau disease
Cyst with an enhancing mural nodule in temporal lobe in teenager having seizures
Pleomorphic Xanthoastrocytoma
- WHO grade II
- presents in 2nd decade of life with seizures
- eosinophilic granular bodies , very pleomorphic but no necrosis and no microvascular proliferation
microvascular proliferation, necrosis, pseudopalisading around areas of necrosis
GBM
Most common primary brain tumor to bleed
Oligodendroglioma–has delicate branching capillaries that look like chicken wire
perivascular pseudorosettes
A vessel at the center of the rosette
Ependymoma
dural tail and homogenous enhancement on MRI
meningioma
Pathology with whorls, psammoma bodies, positive staining for EMA (epithelial membrane antigen)
Desmosomes on electron microscopy
meningioma
Aggressive meningiomas
choroid, clear cell, rhabdoid, papillary
Tumor with Homer Wright Rosettes
Histology: cytoplasmic processes are in the center of the rosette
PNETs=small round blue cell tumors
Ex: medulloblastomas, pineoblastomas, retinoblastomas
Medulloblastoma=most common intracranial PNET
Retinoblastoma=Homer Wright Rosette AND Flexner-Wintersteiner rosettes (true rosettes=have central lumen)
Tumor in Gorlin’s syndrome
medulloblastoma, defects in PTCH gene
Brain Tumor in Li-Fraumeni syndrome
diffuse astrocytomas
Tumor in Turcot’s syndrome
Glioblastoma or medulloblastoma
Metastatic tumors that cause hemorrhage in brain
Melanoma, choriocarcinoma, renal cell carcinoma, bronchogenic, thyroid
tumors of filum terminale
myxopapillary ependymom and paraganglioglioma
amphiphysin paraneoplastic syndrome and cancer assoc.
Stiff person syndrome, encephalomyelitis
small cell lung ca., breast
