Neuro CBL Flashcards
How should suspected stroke be evaluated in ED?
ABC, blood glucose
A good history is key - when were they last seen well or time of onset?
Did they have a seizure?
Medical history that may predispose to stroke
Medication e.g. oral anti-coags
IV access - blood tests
Diff dx of stroke?
Migraine Seizure Hypoglycaemia Tumour or space occupying lesion Peripheral neuropathy Syncope Functional weakness
Total anterior circulation syndrome (TACS)
Contra-lateral hemiparesis
Contra-lateral hemianopia
Higher dysfunction - e.g. dysphagia
Posterior anterior circulation stroke (PACS)
When 2 out of 3 of TACS present -
Contra-lateral hemiparesis
Contra-lateral hemianopia
Higher dysfunction - e.g. dysphagia
or isolated dysphagia
Different lacunar stroke presentations
Pure motor/hemiparesis
Ataxic hemiparesis
Dysarthria/clumsy hand
Pure sensory stroke
Posterior circulation stroke (POCS) symptoms
Cranial nerve palse with contralateral motor/sensory defect
Bilateral motor or sensory defect
Eye movement disorder
Cerebellar signs
Isolated homonymous hemianopia
Which tests requested in stroke?
FBC, UE, CRP, LFT, Lipid profile, glucose, coag profile
Exclusion of hypoglycaemia is mandatory - treatment of hyperglycaemic px with thrombolysis is detrimental!
12 lead ECG
Cranial imaging
Role of imaging in stroke?
To exlude mimics (tumours)
Distinguish ischaemic vs haemorrhagic
Identify site of thrombus
Which imaging used in stroke?
CT first line - non contrast CT can be supplemented by CT angiogram
MRI first line in advanced centres or for minor strokes where it wont be picked up by CT - MRI sequence known as diffusion weighted imaging is v. sensitive for detection of stroke
What should a px with acute stroke be managed with?
A CT scan showed occlusion
<4.5 hr time window for intra-venous thrombolysis
Alteplase is the licensed thrombolytic drug
If px presents early, could consider IVT followed by MT
Px should be admitted to stroke unit!! (easy marks)
Recombinant tissue plasminogen activator (rtPA) - effect?
Precipates reperfusion of a potentially salvageable tissue
Most feared complication of IVT?
Secondary haemorrhagic transformation
What are the cascade of events when blood flow to the brain drops below a critical threshold?
1) excitotoxity
2) peri-infarct depolarisation
3) oxidative stress
4) inflammation
5) apoptosis
Mechanism of cell death after stroke?
Tissue doesn’t immediately die - there is a time window when the tissue is compromised but is potentially salvagable.
Ischaemia vs infarction?
Hypoperfused and hypoxic tissue = ischaemic, doesn’t necessarily imply reverisble tamage
Only when infarction ensues is the ischaemic region irreversibly damaged
Day 2 after stroke - CT angiogram - calcified atheroma affecting carotid arteries and arch of aorta.
Echocardiogram showed left ventricular hypertrophy
Total cholesterol 6
What medications should now be commenced?
Antiplatelets -
evidence of aspirin being effective (not until 24hrs after IVT)
clopidogrel 75mg once daily
Aspirin 75mg and dipyridamole considered if px intolerant to clopidogrel
Statins - prevent further stroke - atorvastatin and simvastatin
Antihypertensives - not given in acute period, once px is stable - ACE inhibitor and thiazide diuretic
Which other therapies can be given after stroke?
Physio Occ health Speech therapy Smoking cessation Dietician
Which other therapies can be given after stroke?
Physio Occ health Speech therapy Smoking cessation Dietician
Uthoff’s phenomenon
Seen in demyelination - symptoms are worse with exercise (heat)
Significance of PMH of optic neuritis?
Inflammation of optic nerve presents with pain on eye movement and visual blurring
MS presents with optic neuritis in 20% of cases - 50% of those with MS will have it at some stage
Important history questions for MS diagnosis?
Tick bites? - lyme disease is an MS mimic
Illicit drugs
Do they drive? DVLA needs to be informed
Signs of optic neuritis?
Red desaturation
Relative afferent pupillary defect
Optic disc pallor (implies atrophy)
Hoffman’s sign
Upper motor neuron (UMN) sign - parallels the extensor plantar sign in the lower limb
It is positive when there is flexion of the ipsilateral thumb after tapping the nail bed of the third finger