Neuro Flashcards
patterns of PRES
- parieto-occipital lobes
- holohemispheric at watershed zones
- superior frontal sulcus
difference between porencephaly & schizencephaly
- porencephalic cyst CSF filled lined with reactive gliosis
2. schizencephaly lined by grey matter
carbon monoxide poisoning
bilat globi pallidi necrosis
what lines virchow-robin spaces
pia
HIV encephalitis
- progressive atrophy and symmetric, periventricular or diffuse patchy/confluent white matter disease
- characteristic sparing of the subcortical-U fibers
cribriform plate is in the superior aspect of what bone?
ethmoid
which show restricted diffusion?
medulloblastoma, ATRT, ependymoma
medulloblastoma
ATRT
contents of meckels cave
CSF (90%)
fascicles CN V
trigeminal/semilunar/Gasserian ganglion
(posterolateral to cavernous sinus)
only nerve to exit dorsal brainstem
CN IV
trochlear
tram track calcification along optic nerve
optic n meningioma
recurrent laryngeal nerve sits in here bilaterally
tracheoesophageal groove
bilat vestibular schwannomas
NF2
NF2 mutation
22q12
artery of percheron infarct
central midbrain
medial thalami
NF 1 mutation
17q11.2
auto dom
100% penetrance
antibody in neuromyelitis optica
anti NMO IgG
against aquaporin 4
CN nuclei in the medulla
CN 9, 10, 11, 12
CN 7 nuclei
mid pons
normal T1 signal vertebral bodies
brighter than disc
stages of neurocysticercosis
- Vesicular (viable larva): small 10mm cysts w scolex, follows CSF, no edema
- Colloidal (dying larva): inflammation, hyperintense to CSF, enhancement, surrounding edema
- Granular nodular (healing): cyst involutes, wall thickens, edema ↓
- Nodular calcified (healed): no edema, MR black dots
cause of neurocysticercosis
taenia solium
findings of NFI
‘substance’
- waxing/waning WM lesions (UBO, FASI)
- optic n glioma
- optic pathway glioma
- brain gliomas (brainstem, cerebral, basal ganglia)
- [plexiform] neurofibroma
- vascular dysplasia
- cafe au lait spots
- dysplastic skeletal lesions
findings of NFII
‘layers’
- multiple CN schwannomas
- meningiomas
- spinal tumors/ependymomas
MISME - multiple inherited schwannomas meningiomas and ependymomas
clinical criteria of NFI
2+ of:
≥ 6 café au lait spots ≥ 15 mm adults or 5 mm children
≥ 2 neurofibromas or 1 plexiform neurofibroma
Axillary/inguinal freckling
Visual pathway glioma
≥ 2 iris hamartomas (“Lisch nodules”)
Distinctive bony lesion (sphenoid wing dysplasia, thinning of long bone ± pseudoarthrosis)
1st-degree relative with NF1
% inverted sinonasal papilloma convert to/coexist w/ SCCa
10%
gene affected in NFIII (schwannomatosis)
SMARCB1
length of MS spinal lesions
usually <2 vert bodies
length of transverse myelitis lesions
usually >2 vert bodies
most common intramedullary neoplasm in adults
ependymoma
second most common intramedullary neoplasm in adults
astrocytoma
most common intramedullary spinal neoplasm in kids
astrocytoma
length of NMO lesions
usually >3 vert bodies
criteria for NMO (Devic)
2/3 of:
- Contiguous cord lesion 3 or more segments in length
- initial brain MR nondiagnostic for MS
- NMO-IgG seropositivity
cannot distinguish NMO from this if optic neuritis and myelitis on 1st scan:
ADEM - acute disseminated encephalomyelitis
mutation in CADASIL
NOTCH3 - chromosome 19
stroke in middle aged, healthy adults
think CADASIL
classic triad susac syndrome
Encephalopathy
Branch retinal artery occlusions
Hearing loss
most common meningitis bugs
- strep pneumo
- n meningitidis
- haemophilus influenzae
most common CNS fungal infection
cryptococcosis
most common CNS infection worldwide
cysticercosis
most common tumor in chronic temporal lobe epilepsy
ganglioglioma
association with dysplastic cerebellar gangliocytoma (lhermitte-duclos disease)
cowden syndrome
10q23
1 CNS neoplasm in tuberous sclerosis
subependymal giant cell astrocytoma
most common tumor in cauda equina region
myxopapillary ependymoma
glomus tympanicum paraganglioma vs glomus jugulare –> floor in tact vs destroyed
in tact = tympanicum; destroyed = jugulare
only CN withIN the cavernous sinus
CN6 abducens
‘cold’ spondylodiscitis causes
Tb
Brucella
rhomboencephalitis involves what
hindbrain = cerebellum and brainstem
bacteria in lemierre’s
Fusobacterium necrophorum
gradenigo syndrome triad & cause
- otitis media
- periorbital pain (CN V)
- abducens palsy (CN VI)
cause: petrous apicitis
association of T2 FLAIR mismatch
highly specific for IDH-mutated 1p/19q non-codeleted astrocytoma
(vs other lower grade gliomas, oligodendroglioma)
most common met to parasellar region
breast ca
syndrome caused by compression of tectal plate
parinaud syndrome
- upward gaze paralysis
- pupillary light dissociation
- nystagmus
central Ca2+ pineal gland
exploded Ca2+ pineal gland
- germinoma
- pineoblastoma
1 extraaxial hematoma
traumatic SAH
2 extraaxial hematoma
acute subdural
terson syndrome
intraocular hemorrhage with SAH
recurrent artery of Heubner supplies…
- head and anteromedial caudate nucleus
- anterior limb internal capsule
medial lenticulostriate arise from?
lateral?
A1
MCA
calcifications of pineoblastoma and germinoma
blastoma blasts apart the Ca2+
germinoma enGulfs the Ca2+
causes of convexal SAH (#10)
- dural sinus and cortical vein thrombosis
- arteriovenous malformations
- dural arteriovenous fistulas
- arterial dissection/stenosis/occlusion
- mycotic aneurysm
- vasculitides
- amyloid angiopathy
- coagulopathies
- RCVS
- posterior reversible encephalopathy syndrome
inheritance of sturge weber
sporadic
path of CN 6 (abducens)
- front of pons (medial to 5)
- up durrelos canal (clivus)
- through cavernous sinus
- up through superior orbital fissure
- orbit
- lateral rectus
brain tumor classically Ca2+
oligodendroglioma
cerebrovascular malformations w/ arteriovenous shunt
- AVM
- dural AV fistula
- vein of galen malformation
wyburn mason syndrome
AVMs of retina and brain
optic canal contents
optic nerve CNII
ophthalmic artery
superior orbital fissure contents
CN III CN IV CN V1 CN VI sup'r and inf'r ophthalmic veins
longest cranial nerve
CN IV - trochlear
posterior decussation
Marchiafava-Bignami disease
rare, alcoholics
osmotic demyelination & necrosis of corpus callosum central fibers (sandwich sign on sagittal)
FLAIR hyperintense, nonenhancing T1 hypointense
Dandy Walker malformation
- large posterior fossa
- cyst extending posteriorly from 4th ventricle
- vermian agenesis/hypoplasia
- torcular-lambdoid inversion
Ramsay Hunt syndrome
shingles/herpes zoster of facial n
- VZV reactivation in geniculate ganglion
- triad: ear pain, facial paralysis, painful vesicular eruption involving EAC, pinna, tongue or hard palate
oxyhemoglobin: time, RBC, T1 and T2 signal
hyperacute (<1 day)
RBC intact
T1 iso
T2 bright
deoxyhemoglobin: time, RBC, T1 and T2 signal
acute (1-3 days)
RBC intact
T1 iso
T2 dark
methemoglobin (intracellular): time, RBC, T1 and T2 signal
early subacute (3-7 days)
RBC intact
T1 bright
T2 dark
methemoglobin (extracellular): time, RBC, T1 and T2 signal
late subacute (7 to 14-28 days)
RBC lysed
T1 bright
T2 bright
hemosiderin: time, RBC, T1 and T2 signal
chronic (>14-28 days)
RBC lysed
T1 dark
T2 dark
ecchordosis physaliphora
ectopic notochord remnant
anywhere from dorsum sella to sacrum
Aunt Minnie: clival defect/cystic lesion with sclerotic margins
Tornwaldt cyst
- benign midline nasopharynx mucosal cyst
- high T2 signal
- notochordal remnant
Wallenberg/lateral medullary syndrome
occlusion of intracranial VA and/or PICA -> infarct of lateral medulla
- dysphagia (nucleus ambiguus), dysarthria, dysphonia
- ipsilat loss of pain in face
- contralat loss of pain & temp in body
+/- ataxia
embryonic carotid-basilar anastomoses
- persistent trigeminal artery (btwn cavernous ICA and basilar artery; Neptune’s trident)
- persistent hypoglossal artery (btwn prox cervical ICA at ~C1-2 level and BA; courses along CN XII through hypoglossal canal)
- persistent otic artery (rare)
- proatlantal/intersegmental artery (rare)
persistent stapedial artery - embryology, course
- stapedial a transiently present in N fetal devel, connecting branches of future ECA to ICA
- arises from C2/petrous ICA
- pass thru stapes footplate, doubles size of anterior/tympanic seg of facial n
- intracranially becomes middle meningeal artery
- assoc w aberrant ICA
persistent stapedial artery - CT findings
- absence of foramen spinosum
- enlarged tympanic seg of facial n (contains soft tissue)
aberrant ICA - course, clinical
- laterally displaced ICA
- enters posterior middle ear cavity from below and hugs cochlear promontory as it crosses middle ear cavity
- then resumes N expected course as it joins post-lat margin of horizontal petrous ICA
- pulsatile tinnitus, vascular retrotympanic mass in anteroinferior mesotympanum
- mimics glomus tympanicum
- assoc w persistent stapedial a
aberrant ICA - imaging CT & angio
CT:
- tubular lesion crossing middle ear cavity from posterior to anterior
- soft tissue density lying on cochlear promontory
Angio:
- angulation resembling a 7, change in contour and caliber (pinched appearance)
CADASIL - imaging
- symmetric high T2 subcortical WM
- anterior temporal lobes + external capsules
+ lacunar infarcts
CADASIL - clinical
recurrent stroke/TIA + migraine -> premature dementia
young adult
reversible cerebral vasoconstriction syndrome
multifocal segmental arterial constrictions
- multiple vascular territories
- beaded appearance
high res wall imaging: +/- thickened wall, reduced lumen; no/minimal enhancement
convexal SAH, strokes
moyamoya - imaging
progressive stenosis of distal (supraclinoid) ICA and proximal CoW, eventual occlusion
anterior > posterior circulation
enlarged/innumerable basal perforating arteries, lenticulostriate collaterals
puff of smoke
children stroke, adults bleed
ivy sign in moyamoya
tubular branching FLAIR hyperintensities within sulci
represent cortical arterial branches that appear FLAIR hyperintense d/t slow collateral flow
+ vivid contrast enhancement
age of esthesioneuroblastoma (olfactory neuroblastoma)
> 50
most common benign orbit lesion adult
hemangioma
most common suture to close prematurely
sagittal
Prussak space boundaries
lateral: pars flaccida & scutum
superior: lateral malleal ligament
medial: neck of malleus
(subcomponent of the lateral epitympanic space)
nuc med imaging for esthesioneuroblastoma
- neuroendocrine tumor –> somatostatin receptor
- octreotide
- MIBG
- DOTATATE
Spetzler Martin scale for AVMs
predicts surgical morbidity/mortality
ranges from 1-5 pts:
- size: <3cm (1), 3-6cm (2), >6cm (3)
- location: noneloquent (0), eloquent area of brain (1)
- venous drainage: superficial (0), deep (1)