Neuro

Question 1

What are the different presentations of childhood suprasellar lesions?

Answer 1

Diabetes insipidus = eosinophylic granuloma
Precocious puberty = hypothalamic hamartoma
Growth retardation = craniopharyngioma

Question 2

What is the mnemonic for childhood orbital masses?

Answer 2

LO VISION
L = Leukemia
O = Optic nerve glioma
V = Vascular malformation (hemangioma, lymphangioma)
I = Inflammation
S = Sarcoma (rhabdomyosarcoma)
O = Opthalmopathy (orbital pseudotumor)
N = Neuroblastoma

Question 3

How does the distribution vary between HSV-1 and HSV-2 infection?

Answer 3

HSV-1: fronto-temporal. Often hemorrhagic

HSV-2: widespread/generalized

Question 4

Which tumors lodge in cranial sutures, causing widening?

Answer 4

Leukemia

Neuroblastoma mets

Question 5

Which peaks are used for MRS?

Answer 5

Creatine (Cr) - cellular energy/metabolism
Choline (Ch) - cell membrane synthesis
N-acetyle aspartate (NAA) - marker of neural integrity
Lactate - not in normal pt. Marker of inflammation/infarct