Nervous System II - Synapses Flashcards
Process by which many neurons project onto one postsynaptic neuron
Convergence
Two types of post-synaptic activation
EPSP - excitatory post synaptic potential IPSP - inhibitory post synaptic potential
EPSPs ___polarize the postsynaptic membrane
Depolarize
Two types of synapses
- Electrical 2. Chemical
Mechanisms of presynaptic modulation
- NT levels 2. Ca2+ levels 3. Presynaptic facilitation 4. Presynaptic inhibition
Synapse of an axon with another axon
Axoaxonic synapse
The adding effects of graded potentials are referred to as __________
Summation
Post synaptic activations are caused by ______ channel activation, leading to a change in __________
Ligand-gated channel activation (via NT) Leads to a change in postsynaptic potential
Synapses occur in which two locations
- Another neuron 2. Effector organs
Process by which one neuron projects onto many
Divergence
IPSPs ___polarize the postsynaptic membrane
Hyperpolarize
Two types of summation
Temporal and spatial
Eight phases of communication across a synapse from 1. Action potential to removal of NT (6-8)
- AP 2. Voltage-gated Ca2+ channels open 3. Ca2+ triggers vehicle exocytosis 4. NT diffuses into synapse and binds to receptor 5. Cellular response Removal of NT via: 6. Depredation 7. Reuptake 8. Diffusion
Inhibitory NTs cause ___ and ____ channels to open, causing ___ influx and ___ efflux
K+ and Cl- channels open; K+ efflux and Cl- influx
Synapse of an axon and a dendrite
Axodendritic synapse
_____________: the summing of input from various synapses at the axon hillock of the post-synaptic neuron
Neural integration
Synapse of an axon with a cell body
Axosomatic synapse
Postsynaptic mechanisms (4)
- The many types of receptors for each type of NT 2. Receptor desensitization 3. Electrical state of postsynaptic membrane 4. Drugs and diseases
How much is the synaptic delay between arrive of AP and change in postsynaptic Vm
0.5-5 mace
Type of synapse that allows for presynaptic facilitation and inhibition
Axoaxonic
The regulation of communication across a synapse
Presynaptic modulation
Neural toxins that prevent inhibition
Tetanus, strychnine