Nervous System Flashcards
describe the structure of a neuron**
dendrite that receives the signal
cell body(soma) that contains the nucleus
axon hillock where the action potential starts
axon is the conducting fibre
what does myelin do for the axon
increases the rate of transmission by insulating the electrical impulse
grey vs white matter
grey = cell bodies
white - myelinated axons
how is myelin made
Schwann cells in the PNS
oligodendrocytes in the CNS
what is saltatory conduction
action potential jumps from one node of ranvier to another to speed up the signal in a myelinated axon
how is the resting potential generated in a neuron
Na/K pump moves 3 Na out of the cell and 2 K in
inside becomes more negative and outside more positive
the rate Na passively diffuses back into the cell increases until it equals the rate its pumped out, K diffuses out of cell due to concentration gradient until it equals the force of the electrochemical gradient (wants to come in because inside is - charge)
when rates reach equilibrium a relative excess negative charge becomes present inside the membrane compared to outside
why can the equilibrium potential of K be used to approximate the resting potential of a neuron
at rest neuron is much more permeable to K
K is leaking out so positive charge is escaping
about -60-70 in the cell
how can the Nernst equation be used to calculate the resting potential of a neuron
take the negative ln of the ratio of Kintracellular/Kextracellular
so if intracellular>extra the ln will be positive so the answer is a negative membrane potential
and if extra>intra the ln will be negative so the answer is positive
where would electrical synapses be found
these are fast so would be in cardiac and visceral smooth muscle
how do chemical synapses use neurotransmitters to initiate a new action potential in a different cell*****
- small vesicles filled with neurotransmitter rest inside the presynaptic membrane of the synaptic knob
- when action potential arrives Ca voltage gated channels open allowing Ca influx
- influx causes neurotransmitters to be released into the synaptic cleft via exocytosis
- neurotransmitter diffuses across the synaptic cleft by Brownian motion and attaches to receptors on the postsynaptic neuron
- post synaptic neuron becomes permeable to ions which move in to generate a new action potential
depolarization of a action potential
voltage gated channels open at a certain voltage
voltage gated sodium channels allow Na to flow into the cell making it more positive
how do local anesthetics work
block voltage gated Na channels on primarily pain neurone because they have small axonal diameters with little myelin
what happens at threshold potential -50
even more Na can enter through positive feedback mechanism
the action potential propagates along the membrane by depolarizing adjacent sections
cell becomes +50
depolarization of the action potential
K flows out of the cell increasing the negativity in the cell
hyper polarization of the action potential
K channels are slow to close and the the inside of the cell becomes more negative than the resting potential and prevents the immediate initiation of a new action potential