Nervous System Flashcards
Nervous Sys
Master controlling and communicating system of body
How does nervous sys communicate?
Cells communicate via electrical and chemical signals,
How are the those signals described?
Rapid and specific
Primary cell of the nervous system
is the neuron
Neurons are the key to what?
The key to neural transmission
Sensory input –
info gathered by sensory receptors about internal and external changes (cold or hot)
Integration-
processing and interpretation of sensory input and decides what actions are required
Motor output-
activation of effector organs (muscles and glands) yields a response
5 parts after stimulus but before response in simple reflect arc
- Receptor
- sensory neuron
- integration center
- motor neuron
- effector
Central nervous system (CNS) parts and location
Brain and spinal cord of dorsal body cavity
CNS job 3 parts
- Integration and control center
- Interprets sensory input and dictates motor output
- Motor output is based on reflexes, past experience, and/or current situation
Peripheral nervous system (PNS) Location
The portion of the nervous system outside CNS
PNS Consists mainly of
nerves that extend from brain and spinal cord
Two types of nerves in PNS
Spinal and Cranial Nerves
Spinal nerves
to and from spinal cord
Cranial nerves
to and from brain
PNS response simple term (common)
FIGHT OR FLIGHT
Histology of nervous tissue
Highly cellular; little extracellular space
Tightly packed
What are the 2 principal nervous cell types?
Neuroglia
Neurons (nerve cells )
Neurons (nerve cells )
excitable cells that transmit electrical signals
Neuroglia
small cells that surround and wrap delicate neurons: AKA glial cells, 6 types
6 types of neuroglia
Astrocytes (CNS) Microglial cells (CNS) Ependymal cells (CNS) Oligodendrocytes (CNS) Satellite cells (PNS) Schwann cells (PNS)
What neuroglia is most abundant?
Astrocytes (CNS)
Astrocytes (CNS)
Most abundant, versatile, and highly branched glial cells with radiating processes that
What do astrocytes cling to?
Cling to neurons, synaptic endings, and capillaries
Astrocyte function
Functions include
Support and brace neurons and anchor them to their nutrient supply
Play role in exchanges between capillaries and neurons
Guide migration of young neurons
Control chemical environment around neurons and calcium concentration
Respond to nerve impulses and recycle neurotransmitters
Influence neuronal functioning
Participate in information processing in brain
Describe Microglial cells (CNS)
Small, ovoid cells with thorny processes that touch and monitor neurons
Microglial cells (CNS) monitor
Monitor the health of neurons then migrate toward injured neurons
Microglial cells (CNS) transform
Can transform into a type of macrophage to phagocytize microorganisms and neuronal debris
Why are microglial cells vital?
Important because immune cells aren’t very permeable through the blood-brain barrier
Describe Ependymal Cells
Range in shape from squamous to columnar
Ependymal Cells may be
ciliated
Ependymal Cells line
Line the central cavities of the brain and spinal column
Ependymal Cells form
Form permeable barrier between cerebrospinal fluid (CSF) in cavities and tissue fluid bathing CNS cells
Oligodendrocytes are
branched cells
Oligodendrocytes processes
Processes wrap CNS nerve fibers, forming insulating myelin sheaths thicker nerve fibers
What gets damaged in MS?
Oligodendrocytes
Autoimmune disease is when
immune system attacks itself, they use chemo to stop immune response they don’t know why human body does this.
Different types of MS
Satellite cells Function
similar to astrocytes of CNS
Surround neuron cell bodies in PNS
Satellite cells
Surround all peripheral nerve fibers and form myelin sheaths in thicker nerve fibers
Schwann cells (neurolemmocytes)
Schwann cells (neurolemmocytes) Function
Similar function as oligodendrocytes
Schwann Cells (neurolemmocytes) vital to what?
Vital to regeneration of damaged peripheral nerve fibers
Satellite cells anchor
neurons nerves need constant blood flow
Schwann cells have different
mylein sheath in some
Nerve cell are
amitotic, they don’t divide
Neurons
Structural units of nervous system
Neurons size and f(x)
Large, highly specialized cells that conduct impulses
How long do neurons last?
Extreme longevity ( 100 yrs or more if healthy)
Neurons are Amitotic but?
with few exceptions (hippocampus: involved with memory and recall)
Neuron high metabolic rate why?
High metabolic rate—requires continuous supply of oxygen and glucose
All neurons have this?
All have a cell body and one or more processes
Biosynthetic center of neuron does what?
Synthesizes proteins, membranes, and other chems
Biosynthetic center of neuron has what?
Rough ER (chromatophillic substance or nissel bodie) Most active and best developed in body
Neuron cell body has?
Biosynthetic center of neuron
Spherical nucleus with nucleolus
Some contain pigments
In most, plasma membrane part of receptive region
Most neuron cell bodies in CNS
Nuclei – clusters of neuron cell bodies in CNS
Ganglia – lie along nerves in PNS (ganglion)
Ganglia –
lie along nerves in PNS (ganglion
Nuclei –
clusters of neuron cell bodies in CNS
Nucleolus develops what?
ribosomes
Chromatophilc-
stains easily
Neuron Processes
Armlike processes extend from body
Neuron Processes in CNS
Both neuron cell bodies and their processes
Neuron Processes PNS
Chiefly neuron processes
Tracts
Bundles of neuron processes in CNS
Nerves
Bundles of neuron processes in PNS
Two types of neuron processes
Dendrites (afferent**)
Axon (efferent**)
Dendrites In motor neurons how many?
100s of short, tapering, diffusely branched processes
Receptive (input) region of neuron
Large surface area for information collection
Synapses with other neurons (bring info to dend)
Convey incoming messages toward cell body as graded potentials (short distance signals)
In many brain areas fine dendrites specialized
Collect information with dendritic spines
Appendages with bulbous or spiky ends
Dendrites
Receive info from sensory receptors or other neurons
Processes allow large surface cuz a lot of info
Graded potential = ap but shorte distance r, ap goes a meter about
Slightly mylienated, no schwann cells
Specialized due to information goes to specific motor movement ex) vision different from moving arm or leg
Dendrites
Describe Axon Structure
One axon per cell arising from axon hillock
Cone-shaped area of cell body
In some neurons, the axon is short or absent (no msg)
In others, encompasses most of the length of neuron
Some 1 meter long
Long axons called nerve fibers
Occasional branches (axon collaterals)
Branches profusely at end (terminus)
Can be 10,000 terminal branches
Distal endings called axon terminals or terminal boutons
Long axons are called ?
nerve fibers
axon collaterals
Occasional branches
Branches profusely at end
terminus
distal endings are called what?
axon terminals or terminal boutons
more common is axon terminals
Axon absent are during
depol for other cells
Nerve fibers are collections
of axons
axon functional characteristics
Conducting region of neuron
Generates nerve impulses
Transmits them along axolemma (neuron cell membrane) to axon terminal
Secretory region (not where they are produced)
Neurotransmitters released into extracellular space
Either excite or inhibit neurons with which axons in close contact
Carries on many conversations with different neurons at same time (through electrical gradients)
Lacks rough ER and Golgi apparatus (don’t create protein)
Relies on cell body to renew proteins and membranes
Efficient transport mechisms for proteins and memrbanes
Quickly decay if cut or damaged (take a long time to regenerate)
What is the conducting region of the neuron?
axon
What part of neuron generates nerve impulses?
axon
What part of neuron transmits nerve impulses along the axolemma (neuron cell membrane) to axon terminal?
axon
What part of neuron is the secretory region of nerve impulses?
axon
Neurotransmitters released into extracellular space
and cause?
Either excite or inhibit neurons with which axons in close contact
What carries on many conversations with different neurons at same time (through electrical gradients)?
axon
What Lacks rough ER and Golgi apparatus (don’t create protein)?
axon
What Relies on cell body to renew proteins and membranes
axon
What Efficient transport mechisms for proteins and memrbanes?
axon
What will Quickly decay if cut or damaged (take a long time to regenerate)?
axon
Axons conduct info
away from the body
The myelin sheath is comprised of
mylein
Mylein
Whitish, protein-lipoid substance
Segmented sheath around most long or large-diameter axons
Dendrites are always non-myelinated (they have shwann cells)
Myelinated fibers
Function of myelin
Protects and electrically insulates axon
Increases speed of nerve impulse transmission
Nonmyelinated fibers conduct impulses more slowly
Mylein sheath
What is a Segmented sheath around most long or large-diameter axons?
mylein sheath
Dendrites are always non-myelinated or myelinated?
Dendrites are always non-myelinated (they have shwann cells)
2 functions of mylein
Protects and electrically insulates axon
Increases speed of nerve impulse transmission
What fiber conducts nerve impulses more slowly?
nonmyleninated fibers
mylein sheath is similar to what in your afsc?
welding coat on electrode that insulates the weld
jumps arc
Myelination in the PNS
Formed by schwann cells
Wrap around axon in jelly roll fashion
One cell forms one segment of myelin sheath
Myelin sheath
Concentric layers of schwann cell plasma membrane around axon
Outer collar of perinuclear cytoplasm (formerly called neurilemma)
Peripheral bulge of schwann cell containing nucleus and most of cytoplasm
How is myelination formed in PNS?
Formed by schwann cells
Wrap around axon in jelly roll fashion
One cell forms one segment of myelin sheath
What makes up myelin sheath in PNS?
Concentric layers of schwann cell plasma membrane around axon
Outer collar of perinuclear cytoplasm (formerly called neurilemma) is made of what?
Peripheral bulge of schwann cell containing nucleus and most of cytoplasm
Process of Myelination in PNS 3 steps
1.) Schwann cell develops an axon
2.) The Schwann cell then rotates
around the axon, wrapping its
plasma membrane loosely around
it in successive layers.
What gets damaged in ALS?
Myelination in PNS because Schwann cells get damaged and messes everything else up
Plasma membranes of myelinating cells have
less protein
Why do Plasma membranes of myelinating cells have
less protein?
No channels or carriers (don’t conduct electrical impulse)
Good electrical insulator
Interlocking proteins bind adjacent myelin membranes
Nodes of ranvier
(conduction of electrical impulse across the axon)
like arc welding
2 aspects of nodes of ranvier
Myelin sheath gaps between adjacent schwann cells
Sites where axon collaterals can emerge
Nonmyelinated fibers are
Thin fibers not wrapped in myelin; surrounded by schwann cells but no coiling; one cell may surround 15 different fibers
Myelin Sheaths in the CNS formed by
Formed by multiple, flat processes of oligodendrocytes, not whole cells
Myelin Sheaths in the CNS wrap how many axons at once
60 axons at once
Are nodes of ranvier present in Myelin Sheaths in the CNS formed by
Nodes of ranvier are present
No outer collar of perinuclear cytoplasm in Myelin Sheaths in the CNS
No outer collar of perinuclear cytoplasm
size of fibers and covered by what in Myelin Sheaths in the CNS
Thinnest fibers are unmyelinated
Covered by long extensions of adjacent neuroglia
White matter
Regions of brain and spinal cord with dense collections of myelinated fibers – usually fiber tracts
Gray matter
Mostly neuron cell bodies and nonmyelinated fibers
Function in gray matter
processing
What matter has role in MS and axons ?
white matter
Sensory Neurons
Transmit impulse from sensory receptors in skin/organs twd cns (integration)
Almost all are Unipolar
Sensory Neurons are what kind of polar?
unipolar
Where are the sensory neuron cell bodies located?
Cell bodies in ganglia in PNS
Motor Neurons Carry impulsess
from CNS to effectors
Motor Neurons are what polar?
Multipolar
Where are cell bodies of motor neurons located?
Most cell bodies in CNS (except some autonomic neurons)
Interneurons
(association neurons)
Where are interneurons located?
Lie btw motor and sensory neurons
What do interneurons do? Where?
Shuttle signals through CNS pathways where integration of information occurs; most are entirely within CNS
What are 99% of body’s neurons?
interneurons
Where are interneurons confined?
Most confined in CNS
Neurons are highly what (membrane potential)?
irritable
Neurons respond to what > (membrane potential)?
Respond to adequate/threshold stimulus by generating an action potential (nerve impulse) along the axon length
What is the impulse always in neurons regardless of what?
Impulse is always the same regardless of stimulus
what is the resting membrane potential?
Potential difference across membrane of resting cell
Numeric value for resting membrane potential and how come?
Approximately –70 mV in neurons (cytoplasmic side of membrane negatively charged relative to outside)
What is the actual voltage difference numeric value in resting membrane potential?
Actual voltage difference varies from -40 mV to -90 mV
What is membrane in resting potential termed?
Membrane termed polarized
What is the resting membrane potential generated by? 2 things
Generated by:
Differences in ionic makeup of ICF and ECF
Differential permeability of the plasma membrane
How is that generated by Differences in ionic makeup of ICF and ECF
Differential permeability of the plasma membrane? 2 things again
Higher K concentration inside the cell with protein anions creating a negative membrane charge
Large concentration of Na+ outside the cell making the outside environment more positive
Differences in Plasma Membrane Permeability Characteristics in Nerve cell
Impermeable large anionic proteins
Slightly permeable to Na+ (through leakage channels)
25 times more permeable to K+ than sodium (more leakage channels)
Potassium diffuses out of cell down concentration gradient
Quite permeable to Cl–
What happens with K+ during plasma membrane resting potential in nerve cell?
More potassium diffuses out than sodium diffuses in
What does Na+ K+ Pump do in resting membrane potential of nerve cell?
Sodium-potassium pump stabilizes resting membrane potential
How does sodium potassium pump work in resting memb potential in nerve cell?
Maintains concentration gradients for Na+ and K+
3 Na+ pumped out of cell; 2 K+ pumped in
Membrane potential changes when
Concentrations of ions across membrane change
Membrane permeability to ions changes
Changes produce two types signals
Graded potentials
Action potentials
Graded potentials
Incoming signals operating over short distances
Action potentials
Long-distance signals of axons
What do changes in membrane potential do in nerve cells?
Changes in membrane potential used as signals to receive, integrate, and send information
Terms of change of membrane potential are relative to what potential?
Terms describing membrane potential changes relative to resting membrane potential
What is occurring in depolarization of nerve cell membrane?
Decrease in membrane potential (toward zero and above)
Inside of membrane becomes less negative than resting membrane potential
Increases probability of producing a nerve impulse
Either graded or action potential
depolarization increases the probablity of what? what are they called?
Increases probability of producing a nerve impulse
Either graded or action potential
Hyperpolarization what occurs?
An increase in membrane potential (away from zero)
Inside of cell becomes more negative than resting membrane potential)
Hyperpolarization reduces probablity of ?
Reduces probability of producing a nerve impulse
Hyperpolarization is the action of what kind of drugs?
Action of anti-anxiety medicine
Why does hyperpolarization provide the reaction that it does?
No neural stimulus, keeps you relaxed since it reduces probability of producing a nerve impulse
How long are grade potentials and why?
Short-lived, localized changes in membrane potential
Magnitude varies with stimulus strength
Stronger stimulus more voltage changes; farther current flows
Graded potential is what polarization wave?
Either depolarization or hyperpolarization
Graded potential are triggered by what?
Triggered by stimulus that opens gated ion channels
GRADED POTENTIAL current flows and how?
Current flows but dissipates quickly and decays
Graded potentials are signals only over short distances
Positive ions move toward negative charges, therefore the charge flows in one direction
Why does Membrane potential decays with distance?
Because current is
lost through the “leaky” plasma membrane, the voltage declines with
distance from the stimulus (the voltage is decremental).
Consequently, graded potentials are short-distance signals.
What is AP?
Brief reversal of membrane potential with a change in voltage of ~100 mV
How are AP different from GP?
Do not decay over distance as graded potentials do
How does depolarization activate AP?
Depolarizing local currents open voltage-gated Na+ channels
Na+ influx causes more depolarization which opens more Na+ channels ICF less negative
What happens at threshold for depolarizaton to activate AP?
At threshold (–55 to –50 mV) positive feedback causes opening of all Na+ channels a reversal of membrane polarity to +30mV Spike of action potential
Repolarizing phase what happens?
Na+ channel slow inactivation gates close
Membrane permeability to Na+ declines to resting state
Slow voltage-gated K+ channels open
K+ exits the cell and internal negativity is restored
What stops increasing during repolarization
AP spike stops rising
What happens during hyper polarization?
Some K+ channels remain open, allowing excessive K+ efflux
This causes hyperpolarization of the membrane (slight dip below resting voltage)
Na+ channels begin to reset
What does hyperpolzartion do resting voltage?
This causes hyperpolarization of the membrane (slight dip below resting voltage)
What is constantly leaving during hyper polarization?
K constnaly leaving cell causes hyperpolarization
What happens with ions in Resting state?
No ions move through voltage-gated
channels.
Depolarization is caused by what ion?
Na+ flowing into the cell
Repolarization is caused by ion?
K+ flowing
out of the cell.
Hyperpolarization is
caused by
K+ continuing to
leave the cell.
What do not all depolarization events yield?
Not all depolarization events produce APs
What does an axon need to get triggered by?
For axon to “fire”, depolarization must reach thresholdThat voltage at which the AP is triggered
What happens at threshold during depolarization?
At threshold:
Membrane has been depolarized by 15 to 20 mV
Na+ permeability increases
Na influx exceeds K+ efflux
What cycle begins after threshold?
The positive feedback cycle begins
What kind of phenomenon is threshold?
All-or-None phenomenon
An AP either happens completely, or it does not happen at all
What is ALL or none phenomenon ?
All-or-None phenomenon
An AP either happens completely, or it does not happen at all
propagation
increase in numbers
spreading
Propagation allows
AP to serve as a signaling device
AP is a
signaling device
By propagation, what happens with ions?
Na+ influx causes local currents (electrical flow)
how does Na+ influx causes local currents (electrical flow)?
Local currents cause depolarization of adjacent membrane areas in direction away from AP origin (toward axon’s terminals)
Local currents trigger an AP there: From positive to negative, one way propagation
This causes the AP to propagate AWAY from the AP origin
Since Na+ channels closer to AP origin are (propagation)
inactivated no new AP is generated there
Once initiated an AP is what and how so?
self-propagating
In nonmyelinated axons each successive segment of membrane depolarizes, then repolarizes
Propagation in myelinated axons differs
Absolute refractory period is?
When voltage-gated Na+ channels open neuron cannot respond to another stimulus
Absolute refractory period Ensures
that each AP is an all-or-none event
Absolute refractory period Enforces
one-way transmission of nerve impulses
Conduction velocities of neurons
vary widely
Rate of AP propagation depends on
Axon diameter
Degree of myelination
Continuous conduction in unmyelinated axons is slower than saltatory conduction in myelinated axons
Function/ role of myelin sheath
Myelin sheaths insulate and prevent leakage of charge