Nervous and Endocrine Systems Flashcards
What is the basic functional and structural unit of the nervous system?
Neuron
What are action potentials?
electrochemical signals of the nervous system
What is the soma?
central cell body
it contains the nucleus and is where most of the biosynthetic activity of the cell takes place
Neurons have ___ axon and ___ dendrites.
one
many
Neurons with one dendrite are termed _____, and those with many dendrites are ______.
bipolar
multipolar
What direction does an action potential travel?
in one direction, dendrites receive the information and the axons carry it away from the cell body
Axons terminate into ______ _____.
synaptic knobs- which form connections with target cells
What happens when an action potential reaches the synaptic knob?
chemical messengers are released and travel across a very small gap called the synaptic cleft to the target cell
What is the difference between a neuron and a nerve?
neuron- single cell
nerve- large bundle of many different axons from different neurons
What is anterograde movement in neurons?
from the soma to the axon terminus
What is kinesin?
protein motor that drives movement of vesicles and organelles along microtubule in axons
What is the resting membrane potential?
-70 mV
electric potential across the plasma membrane, the interior is negatively charged with respect to the exterior
What two membrane proteins are required to establish the resting membrane potential?
Na+/K+ ATPase
K+ leak channels
The Na+/K+ ATPase pumps __ sodium ions out of the cell and __ potassium ions into the cell with the hydrolysis of one ____ molecule.
3
2
ATP
What form of transport is carried out by the Na+/K+ ATPase?
primary active- uses ATP to drive transport against gradient
What do potassium leak channels allow?
allow only K+ to flow out of the cell down their gradient, they are open all the time
Why is the resting membrane potential negative?
one extra sodium is being pumped out compared to the potassium coming in and the leak channels allow K+ to flow out
Are neurons the only cells with resting membrane potentials?
no all cells have it but they are unique in that they use it to generate action potentials, muscle cells also do this
What would happen to the resting membrane potential if potassium leak channels are blocked?
it becomes less negative because K+ is stuck in the cell
What would happen to the resting membrane potential if sodium ions were allowed to flow down their concentration gradient?
it would become less negative and possibly positive because more sodium ions would flow into the cell
What is depolarization?
change in membrane potential from -70 mV to a less negative or even positive number
What is repolarization?
returns the membrane potential to normal
Why is the cell polarized?
it is negative on the inside and positive on the outside
What do the voltage gated sodium channels allow?
they open in response to a change in membrane potential and allow sodium ions to flow down their gradient into the cell to depolarize it (less negative or positive)
What is the threshold potential?
-50 mV
threshold needed for an action potential to generate
What happens when threshold is reached? below?
the sodium channels are opened fully allowing sodium ions to rush in, down its gradient to depolarize that section of the membrane to about +35 mV before inactivating
below threshold, channels are closed not allowing passage of anything
How does depolarization move down the axon?
when one part of the membrane is depolarized, the part next to it gets slightly depolarized until it reaches threshold, in this way it passes it down the axon
If an action potential starts at one end of an axon, can it run out of energy and not reach the end?
no, action potentials are continually renewed at each point in the axon, once it starts it will propagate without changing amplitude until it reaches a synapse
What will happen to the voltage gated sodium channels when the membrane potential goes from -70 to -60?
none of the channels will open because it has not reached threshold of -50 mV, its all or nothing
What happens in the process of repolarization?
- voltage gated sodium channels inactivate very quickly shutting off flow of sodium ions into the cell
- voltage gated potassium channels open more slowly and stay open longer, as potassium leaves the cell the membrane potential return to negative numbers overshooting resting potential down to -90 mV, then the channels close
- potassium leak channels and Na+/K+ ATPase function to bring back to resting membrane potential
What would be the effect if voltage gated potassium channels were inhibited?
the membrane potential would still be repolarized but it would take a lot longer
If a toxin prevents voltage gated sodium channels from closing, what will happen?
- voltage gated potassium channels will open but not close - they normally close by repolarization
- membrane will not repolarize to normal
What creates the myelin sheath?
Schwann cells from the PNS
Oligodendrocytes in CNS
Would an axon be able to conduct action potentials if its entire length were wrapped in myelin?
no because no ion can enter or exit where there is myelin
Nodes of Ranvier?
periodic gaps in myelin sheath where voltage gated sodium and potassium channels are concentrated
How does the myelin sheath speed up conduction of action potentials?
by forcing the action potentials to jump from node to node (saltatory conduction)
Is the amount of energy consumed by Na+/K+ ATPase more in myelinated or unmyelinated axons?
more in unmyelinated because it has to maintain the resting potential in the whole membrane whereas in myelinated axons it only has to maintain resting potential in the nodes of Ranvier
What is equilibrium potential?
no net movement of ions across the membrane
What is the equilibrium potential of sodium?
+50 mV
no more sodium can come in at this point
What is the equilibrium potential for potassium?
-90 mV
it is too negative that K+ cannot escape the attraction so potassium is driven in
Are there more potassium or sodium leak channels?
potassium because the resting potential is closer to the K+ equilibrium potential
What is the refractory period?
short period of time when the neuron is unresponsive to membrane depolarization
What is the absolute refractory period?
a neuron will not fire another action potential no matter how strong a membrane depolarization is induced
voltage gated sodium channels are inactivated and will not open again until resting membrane potential is reached and the channels have returned to closed
What is the relative refractory period?
a neuron can be induced to transmit an action potential but the depolarization required is greater than normal because the membrane is hyperpolarized
What causes hyperpolarization?
caused by the voltage gated potassium channels not closing yet
If voltage gated potassium channels shut more quickly after repolarization than normal, how would this affect the refractory period?
absolute- not affected because it is due to the inability of sodium channels to open
relative- would be shorter
What is a synapse?
junction between the axon terminus and the dendrites, soma, or axons of a second neuron
could also be axon to organ
two types: electrical and chemical
Electrical synapse?
occur when the cytoplasm of two cells are joined by gap junctions so action potentials spread directly from one cell to another
common in smooth muscle and cardiac muscle
Chemical synapse?
found at the end of axons where they meet their target cells, action potential is converted into a chemical signal
What are the 8 steps in a chemical synapse?
- Action potential reaches the end of an axon, the synaptic knob
- Depolarization of the presynaptic membrane opens voltage gated calcium channels
- Calcium influx into the presynaptic cell causes exocytosis of neurotransmitter stored in secretory vesicles
- Neurotransmitter molecules diffuse across the narrow synaptic cleft
- Neurotransmitter binds to receptor proteins in the postsynaptic membrane, these receptors are ligand gated ion channels
- the opening of these ion channels in the postsynaptic cell alters the membrane polarization
- If the membrane depolarization of the postsynaptic cell reaches the threshold of voltage gated sodium channels, an action potential is initiated
- Neurotransmitter in the synaptic cleft is degraded and/or removed to terminate the signal
What is a common example of a chemical synapse?
neuromuscular junction between neurons and skeletal muscle
What neurotransmitter is released in the neuromuscular junction?
acetlycholine (ACh)
What degrades ACh after a synapse?
acetylcholinesterase (AChE)
What are some neurotransmitters?
Gamma-aminobutyric acid (GABA)
Serotonin
Dopamine
Norepinephrine
If a neurotransmitter, such as ACh, opens a channel that depolarizes the postsynaptic membrane, it is _____.
excitatory
Neurotransmitters that induce hyperpolarization are _____.
inhibitory
What ultimately determines the effect on the postsynaptic cell?
the receptor and its associated ion channels
neurotransmitters can be excitatory and inhibitory depending on the receptors
A presynaptic neuron can release ____ type of neurotransmitter and the postsynaptic neuron can respond to ____ neurotransmitters
one
many
If a neurotransmitter causes the entry of chloride into the postsynaptic cell, is it excitatory or inhibitory?
inhibitory
chloride is negative so it will make the potential more negative making it harder to reach threshold
If an inhibitor of acetylcholinesterase is added to a neuromuscular junction, what will happen with the postsynaptic membrane?
it will be depolarized longer, acetylcholinesterase is not there to degrade ACh so the sodium channels will remain open longer
What causes unidirectional signaling at synapses between neurons?
only the postsynaptic cell has receptors for neurotransmitters
What is summation?
adding the effect of all the impinging synapses on a nuron, add the stimuli
Excitatory postsynaptic potentials (EPSP)?
excitatory neurotransmitters cause postsynaptic depolarization
Inhibitory postsynaptic potentials (IPSP)?
inhibitory neurotransmitters cause these
Temporal summation?
presynaptic neuron fires action potentials so rapidly that the EPSPs and IPSPs pile up on top of each other
EPSP- additive effect is enough to reach threshold depolarization required to start postsynaptic action potential
IPSP- postsynaptic cell will hyperpolarize, inhibiting action potentials
Spatial summation?
All EPSPs and IPSPs from all the synapses on the postsynaptic cell are summed at any give time, if threshold is reached an action potential will fire
What are two types of effectors?
muscles and glands
What happens in a reflex?
a sensory neuron transmits an action potential to a synapse with a motor neuron in the spinal cord which causes an action to occur, brain is not involved
What happens in the muscle stretch reflex?
- long sensory neuron detects stretching of muscle
- signal is transmitted to a motor neuron cell body in the spinal cord, causing muscle to contract
What is a reflex involving two neurons and one synapse?
monosynaptic reflex arc
Inhibitory interneuron?
short neuron which forms an inhibitory synapse with a motor neuron causing a muscle to relax (ex. hamstring in knee reflex)
Reciprocal Inhibition?
concurrent relaxation of the hamstring and contraction of the quads is an example
If a reflex occurs without the involvement of the brain, how are we aware of the action?
- sensory neuron also branches to form a synapse with a neuron leading to the brain
- other sensory info is received after the action is taken
Somatic division of the PNS?
concerned with conscious sensation and deliberate, voluntary movement of skeletal muscle
Autonomic division of the PNS?
involuntary process such as digestion, metabolism, circulation, perpiration
Two subdivisions of the autonomic?
Sympathetic (fight or flight)
Parasympathetic (rest and digest)
What are some effects of the parasympathetic system?
- Gland and motility (digestion) stimulation
- relaxation of sphincters
- bladder contraction (enables urination)
- constriction of airways
- decreased heart rate
- constriction of pupils
- near vision accommodation
- erection/ lubrication
What are some effects of the sympathetic system?
- Gland and motility (digestion) inhibition
- contraction of sphincters
- bladder relaxation (inhibits urination)
- relaxation of airways (opens)
- increased heart rate and blood flow
- sweating and blushing
- pupil dilation
- far vision accommodation
- release of epinephrine
- ejaculation/orgasm
The majority of cell bodies are found in the ____.
CNS
Cell bodies bunched together in the CNS are called _____. Bunched cell bodies in the PNS are called _____.
nuclei
ganglia
Other names for the three subdivisions of the brain:
Hindbrain?
Midbrain?
Forebrain?
Rhombencephalon
Mesencephalon
Prosencephalon
What is the function of cerebrospinal fluid?
shock absorption for brain
exchange nutrients and waste in CNS
What is the spinal cord responsible for?
- relay info to and from brain
- simple spinal reflexes (ex. deep tendon reflex)
- primitive processes like walking, urination, and sex organ function
What does the hindbrain consist of?
medulla, pons, cerebellum
Function of Medulla?
- control autonomic processes such as blood pressure, heart rate, respiratory rate, swallowing, vomiting
- controls reflex reactions such as coughing or sneezing
- relays sensory info to cerebellum and thalamus
Function of Pons?
- controls antigravity posture and balance
- connects the spinal cord and medulla to upper regions of brain
- relays info to cerebellum and thalamus
Function of Cerebellum?
- integrating center
- coordination of complex movement, balance and posture, muscle tone, spatial equilibrium
Function of Midbrain?
- integration of visual and auditory info
- visual and auditory reflexes
- wakefulness and consciousness
- coordinates info on posture and muscle tone
Function of Thalamus?
- relay center for somatic sensation
- relays info between spinal cord and cerebral cortex
Function of Hypothalamus?
- controls homeostatic functions (temp regulation, fluid balance, appetite) through neural and hormonal regulation
- controls primitive emotions such as anger, rage, sex drive
- controls pituitary gland
Function of Basal Nuclei?
- regulate body temp and muscle tone
- coordination of learned movement patterns
- general pattern of rhythm movements (walking)
- subconscious adjustments of conscious movements
Function of Limbic system?
- controls emotional states
- links conscious and unconscious portions of the brain
- help with memory storage retrieval
Function of Cerebral Cortex?
- four lobes with subfunctions
- conscious thorough processes and planning, awareness and sensation
- intellectual function (intelligence, learning, reading, communication)
- abstract thought and reasoning
- memory storage and retrieval
- initiation and coordination of voluntary movement
- complex motor patterns
Function of Corpus Callosum?
connects left and right cerebral hemisphers
What makes up the brainstem?
Medulla, Pons, Midbrain
What is the diencephalon?
thalamus and hypothalamus
What is included in the forebrain?
Diencephalon
Telenchephalon
Left vs Right side?
Left- motor functions of right side of body, dominant, speech
Right- motor of left side, visual and spatial reasoning, music
Function of Frontal Lobe?
initiates all voluntary movement and are involved in complex reasoning skill and problem solving
Function of Parietal Lobes?
general sensations (touch, temp, pressure, vibration) and gustation (taste)
Function of Temporal Lobes?
process auditory and olfactory sensation and involved in short term memory
Function of Occipital Lobes?
process visual sensation
How many pairs of cranial nerves? spinal nerves?
12
31
Cranial nerves convey sensory and motor info to and from the _____. Spinal nerves convey to and from the ____.
brainstem
spinal cord
What is the effect the Vagus nerve has on the heart and GI tract?
decreases heart rate and increases GI activity (part of parasympathetic system)