Nephrotic Syndrome Flashcards
Three types of cellular changes with glomerular disease
proliferative, sclerotic, membranous
Three different ways that diseases of the glomerulus present
focal nephritic, diffuse nephritic, nephrotic
Primary component of glomerulus that’s increased in sclerotic disease
collagen
Primary component of glomerulus that’s increased in proliferative disease
cellular
Pathophysiology of nephrotic syndrome sequelae
glomerular damage–>protenuria (>3.5g/day)—>hypoproteinemia (albumin < 3g/100ml)—> edema, hyperlipidemia and thrombotic disease
Epidemiology of minimal change disease in kids
90% of nephrotic cases in children <10yrs. 50% of cases in older children
What happens glomerulus in minimal change disease?
fusion of podocytes
Treatment for minimal change disease
steroids
Define focal and segmental glomerulosclerosis
presence in some of the glomeruli of segmental areas of mesangial collapse and sclerosis
What patient popns is focal and segmental glomerulosclerosis associated with?
HIV and massive obesity
What is membranous glomerulopathy?
basement membrane thickening with little or no cellular proliferation or infiltration.
T/F membranous glomerulopathy can precede the diagnosis of cancer
true
What metabolic disorder might severe hypoproteinemia lead to?
metabolic alkalosis
How do ACE inhibitors work?
ACE inhibitors relax the efferent arteriole decreasing glomerular pressure. SE is decreased GFR
Most common cause of end stage renal disease
diabetes
