Nephrology: Renal Transplantation

Question 1

Donation

Answer 1

remaining kidney increases function

creatinine does not change

Question 2

Recipient

Answer 2

live related donor - 95% at one year, 72% at five years

Cadaver donor: 88% at one year, 58% at 5 years

Dialysis alone: 30-40% at five years

Diabetics on dialysis: 20% at five years

Question 3

Post-transplant graft rejection

Answer 3

prevent with:

cyclosporine

tacrolimus

mycophenolate

these take survival of graft from 20-30% to 80% and more - miracle drugs

suppress t-cells

also can have graft vs host reactions