Nephrology and GU Flashcards
What is BPH and how might it present?
- BPH= Benign Prostatic Hyperplasia. Testosterone fuelled hyperplasia/ hypertrophy in transitional zone.
- Presentation:
- Frequency
- Urgency
- Nocturia
- Incontinence
- Voiding Sx- hesitancy, poor stream, dribble, intermittence, abdo strainging
- PR- smooth enlarged prostate
Complications of BPH
- UTI
- Acute/ chronic retention –> ?palpable bladder
- Haematuria
- Stone formation
- Obstructive renal failure
- NOT PROSTATE CA
Ix and Tx of BPH
- Ix: (need to rule out cancer)
- Bedside- PR, MSU
- Bloods- U+Es, PSA
- Imaging- Transrectal USS + biopsy
- Advanced- cystoscopy, renal USS ?hydronephrosis
- Tx:
- Cons- reduce caffeine/ alcohol, bladder training, relax when voiding, watchful waiting
- Medical (monotherapy/ combo):
- Tamsulosin (alpha blockers)- reduce tone
- Finasteride- reduce testosterone. SE ED
- Surgical- transurethral. ?resection ?prostatectomy. Risk= impotence
Prostate cancer RF
- = Adenocarcinoma
- Hormonal- testosterone/ IGF-1
- Age
- FHx (BRCA1/2)
- Vasectomy
- Prostatitis
- Ethnicity
- Obesity
- Diet- high calcium/ cadmium
Prastate Cancer 2 week wait
- Feels malignant on PR
- ?PSA in:
- Lower urinary tract Sx
- ED
- Visible haematuria
- –> 2ww if PSA above age-specific range
Presentation of prostate cancer
- 30% men 40-65y
- Incidental - increased PSA
- Lower UT Sx- Hesitance, dribbling, nocturia, poor stream
- Haematuria
- Pain- hips, pelvis, spine
- ED
- Pain on ejaculation
- Renal failure
- Metastatic spread - back pain, weight loss, anaemia
Diagnosis + Ix of prostate cancer
- Bedside- DRE (large + craggy, no sulcus), MSU
- Bloods- FBC, serum PSA >4ng/mL –> 2ww for USS
- Imaging:
- Transrectal USS - size and stage
- X-ray + isotope bone scan
- CT/ MRI - spread
- Special - needle biopsy + histology
Management of prostate cancer by stage
- Confined to prostate:
- Cons- active monitoring + PSA
- Med- hormonal therapy/ tamsulosin for Sx
- Surg- severe Sx/ obstruction. ?radical prostatectomy ?radiotherapy ?brachytherapy (radioactive pellets). Complications of resection- incontinence, retrograde ejac, impotence
- Locally advanced= incurable –> palliation
- 80% adrogen dependent –> hormone therapy. Tx= LHRH agonists (abiraterone, goserelin), anti-androgens. SE: hot flushes, lethargy, ED, gynaecomastia
- Metastatic: Hormone therapy, chemo, radio
- Bone pain- radiotherapy/ bisphosphonates
Presentation, Ix and Tx of prostatitis
- Acute/ chronici infection/ inflammation
- Usually present >35y
- Acute causes= S. faecalis, E. coli
- Presentation:
- Flu like Sx
- Pain - perianal, lower back
- UTIs
- Retention
- Haematospermia
- DRE- swollen/ boggy
- Ix- rule out DDx (abscess, BPH, UTI)
- Tx- analgesia, ABx- levofloxacin
- Chronic = >3m. May not be infective. Tx= NSAIDs, tamsulosin, prostatic massage.
What is renal calculus and what types/ causes are there?
- = Renal stone. crystal aggregates form in collecting ducts –> deposited anywhere in renal tract. Types:
- Calcium oxalate- high PTh, hypercalcaemia, kidney disease, sarcoid, cancer
- Struvite- post-UTI
- Uric acid - gout, high protein diet
- Cystin- abnormal anatomy
Different presentation of renal stones
- ASx
- Renal colic- loin- groin. N+V. Can’t lie still
- Renal obstruction. Upper ureter- mimics appendicitis. Lower- bladder irritability. Bladder/ urethra- pelvic pain, dysuria, inability to void, interrupted flow
- UTI/ pyelonephritis
- Haematuria
- Proteinuria
- Sterile pyuria
- Aneuria
Signs and Sx of renal stones
- ASx
- Aneuria
- Dysuria
- Frequency
- Proteinuria/ Haematuria
- Colic - loin-groin. Restless
- N+V
- +/- UTI
RF for renal stones + prevention
- Dehydration
- Foreign body
- Drugs- ABx, antacides, diuretics
- FHx
- Frequent UTIs
- UT abnormalities
- Diet - high ammonia (red meat), oxalate (chocolate, tea, rhubarb, strawberries)
- Hypercalcaemia
- Prevention- hydration, normal Ca2+ intake, thiazide diuretic, allopurinol in gout
Ix and Tx of renal calculus
- Ix:
- Bedside- urine dip + MSU
- Bloods- FBC, U+Es, Ca2+, PO43-, glucose, bicarbonate, urate
- Imaging- CT KUB, (AXR monitoring known stones)
- Tx:
- Cons- fluids. Stones <5mm pass spont.
- Med- analgesia, nifedipine/ tamsulosin for stones >5mm not passing
- Surg- Stones >5mm not passing with IVT and med managment. Extracorporeal shockwave lithotripsy –> keyhole nephrolitotomy
Diagnosis of AKI
- Serum creatinine 1.5x baseline
- Serum creatinine >26 mmol/L
- UO <0.5mL/kg/h over 6 hours
Raised creatinine and low UO = severe!
Causes of AKI
- Pre-renal:
- Hypotension- absolute (D+V, burns) and relative (HF, sepsis) loss
- Drugs that reduce BF - ACEi
- Renal artery stenosis
- Renal:
- Acute tubular necrosis- contrast, NSAIDs, aminoglycosides
- Gomerulonephritidies (blood, protein)
- Drugs- PPI, cisplatin
- Vasculitis- GPA
- Goodpasture’s
- Systemic- HTN, DM, SLE
- Post-renal:
- Compression- malignancy, BPH, strictures
- Blockage- kidney stones, clots, blocked catheter
Presentation of AKI
- Non-specific! Signs of cause?
- Reduced UO
- Dehydration
- Overload- pulm. + peripheral oedema, raised JVP
- Lethargy
- Acidosis
- Confusion
- Arrhythmias
Nephrotoxic drugs
- NSAIDs
- ACEi
- Contrast
- Aminoglycoside eg gentamicin
- Metformin
- Methotrexate
- Lithium
- ?Diuretics
- DAMN- Diuretics, Aminoglycosides, Metformn, NSAIDs
Ix of AKI
- Bedside- ECG, urine: dip, MSU, ouput, albumin:creatinine. Catheter flushing?
- Bloods- FBC, U+Es, CRP, LFTs, CK, ESR, clotting, phosphate
- Imaging- CXR, renal USS
Tx of AKI
- Cons- encourage oral intake, IVT, catheter for obstruction
- Med:
- Sepsis - ABx
- HF/ overload - furosemide
- Shock - IVT +/- inotropes
- Hyperkalaemia - calcium gluconate, insulin, salbutamol
- Surg- remove blockage
Complications of AKI
AHOPE = indications for renal replacement therapy
- Acidosis <7.15
- Hyperkalaemia
- Oedema
- Pericarditis
- Encephalopathy/ uraemia
Other complications of renal failure- loss of lean body mass, anaemia, bone disease (high PTH, low Ca2+), HTN
Definition of CKD and end stage renal failure
- eGFR <60ml/min/1.732 for >3m
- End stage renal failure= GFR <15mL/min/1.732 or need for renal replacement therapy
Causes and screening of CKD
- Causes:
- DM
- HTN
- Hypercholesterolaemia
- Glomerulonephritis
- Drugs- NSAIDs, lithium, omeprazole
- Polycystic kidneys
- Screening in those at risk: DM, HTN, CVS disease, stones, BPH, frequent UTIs, VUR, FHx
Classification/ stages of CKD
Based on GFR
- >90
- 60-89
- a= 45-59, b= 30-44
- 16-29
- <15
Stages 1-3 can be managed in GP
Signs and Sx of CKD
- Oligouria/ nocturia/ polyuria
- Weight loss
- Oedema + SOB
- Amenorrhoea
- Bone pain
- Fatigue
- Pruritis
- Yellow- uraemic tinge
- Asterixis
- N+V
- Muscle cramps
Ix of CKD
- Bedside- urine: dip, C+S, albumin:creatinine ratio, bence jones protein
- Bloods- FBC (aneamia), U+Es, ESR, glucose, hypocalcaemia, high phosphate, high ALP, high PTH. Immune- ANA, dsDNA, ANCA, GMB, C3/4, Ig, Hep
- Imaging- CXR, AXR/CT KUB, renal USS (usually small), bone x-ray
- Special- renal biopsy
Management of CKD
- Tx the cause! Stop nephrotoxic drugs. Manage the Sx
- Cons- healthy eating, exercise, Na/phosphate/fluid restriction. Phosphate= milk, cheese, eggs
- Med:
- CVS risk- statins, aspirin
- HTN- BP target <140/90 (130/80 in DM)
- Oedema- furosemide
- Bone disease- calcichew, vit D, ca supplements
- Anaemia
- Restless legs- clonazepam
- Renal replacement
What is renal replacement?
- Dialysis: (risk= infection)
- Haemodialysis
- Peritoneal dialysis
- Renal transplant= gold standard.
- Types- deceased, live donor
- Before- check ABO blood group, HLA match
- Contraindications- active infection, cancer, severe heart disease
- After- NB immunosuppression- steroid, monoclonal Ab, tacrolimus
- Complications- bleeding, graft thrombosis, infection, urinary leaks, CVD, rejection