Nephrology

Question 1

What are the three features of antibody mediated rejection in renal transplant?

Answer 1

Histological evidence of acute injury.
C4d staining on peritubular capillaries
Serological evidence of circulating DSAs

Question 2

What features would make you suspicious of acute rejection in renal transplant?

Answer 2

1. New 25% increase in creatinine
2. Worsening hypertension
3. Proteinuria >1gram
4. Plasma donor derived cell free DNA >1%

Question 3

How long do you continue Bactrim prophylaxis post transplant?

Answer 3

6-12 months

Question 4

What is the prophylactic agent for CMV reactivation post transplant and what is the routine duration of therapy?

Answer 4

Valganciclovir

12 months

Question 5

What agent is used post transplant to prevent HSV activation? What is the duration?

Answer 5

Aciclovir

3 months