Nephrology Flashcards
MCD
1. Associations
2. Common presentation
3. Pathopysiology
4. Treatment
- Atopy, Lymphoma, NSAIDS
- Age - 2- 7 yers, Nephrotic Syndrome, Hypertension rare, light Micro - Normal, e Micros- Fusion of Foot process
- T cell and cytokyne mediated damage to GBM
- Prednicelone, Cyclosphospamide,
RPGN
1. similar presentaions
2. Characteristics
- RPGN, Focal Necrotizing GN, Renal Micro PA, CRGN
- rapidly progress in to end stage renal failure
Fibromuscular Displasia
1. Common presentation
- Young Female, Asymmetric kidneys, Hypertension
Good paster’s syndrome/ Anti GBM
1. presentation
2. risk factors
- haemoptesis, renal
rapidly progressive glomerulonephritis(RPG) - Men, Smokers, hydro C inhale, pulmonaary edema, LRT
Hivan treatment
Anti-retroviral therapy
HUS
1. classic presentation
2. management
Traid - microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury
aHUS and MPGN/C3G Spectrum:
aHUS and MPGN/C3G are considered part of a spectrum of diseases caused by genetic or acquired defects in complement regulation
- AKI, MAHA, Thrombocytophenia
2.
Membranous Gromerulonephritis
1. etiology
2. histology
- primary idiopethic - 75% (APLA2)
secondary - Gold, penicilamines, NSAIDS, SLE,malignamcy, infect(hep B, malaria, syphilis) - spike & dome
light micros - thickning of GBM, igG C3 deposits
MPGN,/MCGN
1. Associations
HUS,SLE, Hep -B/C, Immune mediated, complement mediated
1. partial lipodistrophy,
ARPCKD
1. presentation
- PHTN, Liver fibrosis, infancy present
AIN
1. presentation
- drug inmduced, fever, rash, arthralgia
Eosinophilia, white cell cast
wegener’s
fever, weightloss, malaise, pulmonary, renal
- ACR or PCR mor sensitive
- How to measure ACR
- ACR PCR relationship
- ACR Diabetics
- ACR, women high
- spot urine sample
- ACR30= PCR 50
- 3.8
HSP
1. presentation
2. pathophys
- IgA nephropathy, rash, sore throat (2 days prior), haematuria, abdo pain
- Complement damage, mesngial hypecellularity,
GN with low complements
PSGN,SLE, MCGN, bac endocarditis
GN with normal complements
Goodpasterers
conditions associated retro fibrosis
radiotherapy, AAA, Methysergide, infections, medications, and exposure to asbestos, Infections actinomycosis, histoplasmosis, and tuberculosis
Wilms tumor
Beckwith-Wiedemann syndrome associated
under 5
Membranous GN &cortocosteriod
not effective
urinary cyanide nitroprusside test
diagnosis of cystinuria
autosomal recessive pattern
post transplantation of Kidney raised K+ levels
Tacrolimas
K+ level should be monitored
metobolic bone disease in CKD Features
Ph increased (reduced extretion)
PtH increased
Vit D reduced
