Nephrology

Question 1

What antibody is implicated in membranous nephropathy?

Answer 1

Anti-PLA2R

Question 2

What determines whether GN is proliferative or not?

Answer 2

Activation of complement in contact with circulation

Question 3

What determines if primary membranous nephropathy is active/inactive?

Answer 3

Presence of anti-PLA2R

Question 4

Which slit diaphragm protein is implicated in congenital nephrotic syndrome?

Answer 4

Nephrin (NPHS1)

Question 5

Which slit diaphragm protein is implicated in familial FSGS?

Answer 5

Podocin TRPC6 (NPHS2)

Question 6

Which receptor is increased in two thirds of FSHS patients?

Answer 6

Serum soluble urokinase-type plasminogen activator receptor (suPAR)

Question 7

Which subclass of IgA is seen in IgA nephropathy?

Answer 7

IgA1

Question 8

What is the treatment of choice for IgA nephropathy

Answer 8

Blood pressure control only

Question 9

What complement underlies MPGN?

Answer 9

C3 via alterations to C3 nephritic factor and factors H, I and B

Question 10

What is the treatment for MPGN?

Answer 10

BP control, steroids, MMF

Question 11

What is the final common pathway for CKD?

Answer 11

Glomerular sclerosis

Question 12

What is the ideal proteinuric target in CKD?

Answer 12

<0.5-1g/day