Immunology Flashcards
What is the role of C3b in the complement cascade?
Opsonisation of bacteria
What is the role of C3a and C5a?
Chemotaxis
What is the role of C5b?
Initiates formation of the membrane attack complex
Which complement pathway is activated by bacteria-specific membrane markers (such as endotoxin)?
Alternative pathway
Which complement pathway is antibody-mediated?
Classical
Which complement pathway is activated via lectin? (Bacterial membrane sugars)
Lectin pathway
Which two factors protect host cells via breakdown of C3 convertase?
Decay accelerating factor and membrane cofactor protein (DAF and MCP)
What is the role of homologous restriction factor (HRF)?
Inhibits C8 and CD59 activation, thus protecting host cells
Which complements are directly responsible for the formation of the MAC?
C5-9
What are the three earliest cytokines in inflammation?
IL-8, TNF-a, TL-1
What chromosome is the gene responsible for HLA encoding located on?
Chromosome 6
What does the class I region on chromosome 6 code for?
HLA A, B, C, E
What does the class II region on chromosome 6 code for?
HLA-DP, DQ, DR
What does the class III region on chromosome 6 code for?
C2, C4, HSP70, TNF
What markers do TH1 cells produce?
IFN gamma and TNF alpha
What markers do TH2 cells produce?
IL4, 5 and 13
What markers do TH17 cells produce?
IL17, 22 and various chemokines
Which infection response are TH1 cells responsible for?
Viral
Which infection response are TH2 cells responsible for?
Helminths
Which infection response are TH17 cells responsible for?
Bacterial (also responsible for chronic inflammation)
