Nephritities Flashcards
1
Q
post strep glomerulonephritis
A
- subendothelial IgG immune complex deposits
- in children
- HTN
- edema
- brown urine
- high ASO titer
- anti-dnase B
- EM = sub epithelial humps
- tx = supportive
2
Q
lupus nephritis
A
- proteinuria
- ana
- anti-dsdna antibodies
- LN = endothelial deposits cause wire-looping
- Tx = glucocorticoid, ACE-I, statin, immunosuppressants (cyclophosphamide)
3
Q
granulomatosis w/ polyangitis
A
- affects kidneys, lungs, upper airways
- microscopic hematuria
- pulmonary nodules/ infiltrates
- saddle nose, sinus dz, palate granulomas
- c-ANCA
- tx = glucocorticoid, cyclophosphamide
4
Q
goodpasture syndrome
A
- IgG antibodies agains GBM
- proteinuria and hematuria
- cough/ hemoptysis
- pulm infiltrates
- IF = linear deposits
- tx = plasmapheresis, glucocorticoid
5
Q
IgA nephropathy
A
- IgA immune complexes in mesangium, mesangial proliferation
- sequela of URI/tonsillitis
- seen in kids w/ henloch-scholein purpura
- EM/IF = mesangial deposits
- tx = ACE-I, glucocorticoid, cyclophosphamide
6
Q
alport syndrome
A
- type 4 collagen issue, defective basement membrane splitting
- cataracts, hearing, nephritis
- tx = ACE-I, renal transplant
7
Q
Pauci-imune rapidly progressive glomerulonephritis
A
- crescent-shaped fibrin deposits in glomeruli
- microscopic hematuria
- proteinuria
- p-ANCA
- tx = glucocorticoids, cyclophosphamide
- rapid progression to ESRD
