Nephritic Syndrome: SLE Nephropathy Flashcards
1
Q
Definition
A
Lupus nephritis secondary to SLE (ANA deposition in the endothelium)
2
Q
Diagnosis
A
ANA ve+
Anti dsDNA +ve
GOLD STANDARD:
Biopsy and light microscopy: hypercellular glomerulus, thickened basement membrane, endothelial and mesangial proliferation, ‘wire-loop’ appearance; capillary wall thickening in severe disease
Electron microscopy: subendothelial immune complex deposition
Immunofluorescence: granular appearance
3
Q
Treatment
A
Steroids
Hydroxychloroquine
Immunosuppression e.g. cyclophosphamide
