Nephritic syndrome Flashcards
What is the pathophsyiology of goodpasture’s?
Anti-glomerular basement membrane antibodies target type 4 collagen in the glomerular basement membrane
What antibodies are seen in goodpasture’s?
ANti glomerular basement membrane antibodies
What other organ system does goodpasture’s affect?
Lungs - anti GBM membranes affect basement membranes in the lungs
What is the management of goodpasture’s?
Plasma exchange
Steroids
Cyclophosphamide
What is the most common cause of glomerulonephritis?
IgA nephropathy
What is the most common presentation of lupus nephritis?
Diffuse proliferative glomerulonephritis
What antibodies are seen in the blood for diffuse proliferative nephritis?
Anti ds-DNA
ANA
What is alport syndrome?
Defects in type 4 collagen of the basement membrane - caused by inherited X-linked syndrome
What is the presentation of alport syndrome?
Sensorineural hearing loss
Eye problems - retinitis pigmentosa
Nephritic syndrome
