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Year 5 Histopath > Neoplastic Bone Disease > Flashcards

Neoplastic Bone Disease Flashcards

1
Q

Name 4 malignant bone tumours

A 
Osteosarcoma
Chondrosarcoma
Ewings sarcoma
Giant cellOsteosarcoma
Chondrosarcoma
Ewings sarcoma
Giant cellOsteosarcoma
Chondrosarcoma
Ewings sarcoma
Giant cell
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2
Q

What age does osteosarcoma affect?

A

Adolescence

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3
Q

What age does chondrosarcoma affect?

A

> 40 years

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4
Q

What age does Ewing’s sarcoma affect?

A
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5
Q

What age does Giant cell affect?

A

20 - 40 years
F>M20 - 40 years
F>M20 - 40 years
F>M

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6
Q

Which area does osteosarcoma affect most commonly?

A

Knee

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7
Q

Which area does Chondrosarcoma affect most commonly?

A

Axial skeleton
Femur/tibia/pelvisAxial skeleton
Femur/tibia/pelvisAxial skeleton
Femur/tibia/pelvis

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8
Q

Which area does Ewing’s sarcoma affect most commonly?

A

Long bones
PelvisLong bones
PelvisLong bones
Pelvis

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9
Q

Which area does Giant cell affect most commonly?

A

Knee - epiphysis

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10
Q

What is the histology of osteosarcoma?

A

Malignant mesenchymal cells
ALP +veMalignant mesenchymal cells
ALP +veMalignant mesenchymal cells
ALP +ve

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11
Q

What is the histology of osteosarcoma?

A

Malignant chondrocytes

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12
Q

What is the histology of osteosarcoma?

A

Sheets of small round cells
CD99 +ve
T 11:22 translocationSheets of small round cells
CD99 +ve
T 11:22 translocationSheets of small round cells
CD99 +ve
T 11:22 translocation

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13
Q

What is the histology of osteosarcoma?

A

Osteoclast-type multinucleate giant cells on background of spindle/ovoid cells

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14
Q

What is the appearance of osteosarcoma on X-ray?

A

Elevated peristeum (codmans triangle)
Sunburst appearanceElevated peristeum (codmans triangle)
Sunburst appearanceElevated peristeum (codmans triangle)
Sunburst appearance

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15
Q

What is the appearance of Chondrosarcoma on X-ray?

A

Lytic lesion with fluffy calcification
Axial skeletonLytic lesion with fluffy calcification
Axial skeletonLytic lesion with fluffy calcification
Axial skeleton

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16
Q

What is the appearance of Ewing’s sarcoma on X-ray?

A

Onion skinning of perosteum

17
Q

What is the appearance of Giant cell on X-ray?

A

Lytic/lucent lesions right up to articular surface

18
Q

What is seen on X-ray for an osteoid osteoma?

A

Radiolucent nidus with sclerotic rim

19
Q

Which bones are affected in Osteoid Osteoma?

A

Tibia/Femur

20
Q

Which bones are affected in Osteoma?

A

Head + neck

21
Q

Which bones are affected in Enchondroma?

22
Q

Which bones are affected in Osteochondroma?

A

Long bones
PelvisLong bones
Pelvis

23
Q

Which bones are affected in Fibrous dysplasia?

24
Q

Which bones are affected in simple bone cyst?

A

Humerus or femur

25
Which X-ray changes can be seen in Osteoblastoma?
Speckled mineralisation
26
Which X-ray changes can be seen in Osteoid osteoma?
Radiolucent nidus with sclerotic rim
27
Which X-ray changes can be seen in Enchondroma?
``` Lytic lesion Cotton wool calcification Expansile O ring signLytic lesion Cotton wool calcification Expansile O ring sign ```
28
Which X-ray changes can be seen in Osteochondroma?
Well defined bony protuberance from bone
29
Which X-ray changes can be seen in Fibrous dysplasia?
Soap bubble osteolysis Shepherds crook deformity Soap bubble osteolysis Shepherds crook deformity
30
Which X-ray changes can be seen in Simple bone cyst?
Lytic well defined
31
What can be seen in histology of Enchondroma?
Normal cartilage
32
What can be seen in histology of Osteochondroma?
Cartilage capped bony outgrowth
33
What can be seen in histology of Fibrous dysplasia?
Chinese letters (misshapen bone trabeculae)
34
What are the special features of Osteoid Osteoma?
Small benign bone forming lesion | Night pain - relieved by aspirin
35
What are the special features of Osteoma?
Bony outgrowths attached to normal bone Gardner syndrome:  GI polyps + multiple osteomas + epidermoid cysts
36
What are the special features of Enchondroma?
Benign tumours of cartilage Ollier's syndrome = multiple enchondromas Maffuci syndrome = multiple enchondromas + haemangiomas
37
What are the special features of Osteochondroma?
Cartilage capped bony outgrowth Diaphyseal aclasis/heriditary multiple exostoses = multiple exotoses + short stature + bone deformities
38
What are the special features of Fibrous dysplasia?
A bit of bone is replaced by fibrous tissue Albright syndrome = polyostotic dysplasia + cafe au lait spots + precocious puberty
39
What are the special features of Simple bone cyst?
Fluid filled unilocular

Year 5 Histopath (17 decks)

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