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neoplasm - conditions Flashcards

1
Q

ulcerative colitis - neoplasm

A

colon adenocarcinoma

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2
Q

chronic atrophic gastritis - neoplasm

A

it predisposes to gastric adenocarcinoma

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3
Q

postsurgical gastric remnants - neoplasms

A

it predisposes to gastric adenocarcinoma

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4
Q

aids predispose to (neoplasm)

A
  1. aggressive lymphoma (non-Hodgkin)

2. Kaposi sarcoma

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5
Q

Down syndrome - neoplasm

A

ALL, AML

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6
Q

immunodeficiency predisposes to (neoplasm)

A
  1. lymphoma
  2. melanoma
  3. renal cell carcinoma
  4. SCC of skin
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7
Q

Li-Fraumeni syndrome predisposes to (neoplasm)

A

various cancers at young age (eg. sarcoma, breast, leukemia, adrenal gland)

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8
Q

radiation exposure - high risk of developing (neoplasm)

A

leukemia, sarcoma, papillaty thyroid cacner, breast cancer

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9
Q

actinic keratosis - precursor to (neoplasm)

A

squamous cell carcinoma of the skin

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10
Q

paget disease of bone predisposes to (neoplasm)

A
  1. osteosarcoma

2. fibrosarcoma

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11
Q

dematomyositis predisposes to (neoplasm)

A

visceral malignancy (particularly genitourinary)

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12
Q

polymyositis predisposes to (neoplasm)

A

visceral malignancy (particularly genitourinary)

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13
Q

dermatomyositis and polymyositis predispose to visceral malignancy particularly

A

genitourinary

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14
Q

Xeroderma pigmentosum predisposes to

A

skin cancer (BCC, SCC, melanoma)

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15
Q

Oncogenes role in cancer

A

gain of function –> increase cancer risk

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16
Q

oncogenes and cancer - need damage … allele (number)

A

only 1

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17
Q

tumor suppressor genes role in cancer

A

loss of function –> increase cancer risk

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18
Q

tumor suppressor genes and cancer - need damage … allele (number)

A

both allele

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19
Q

BCR-ABL - oncogene or tumor suppressor gene?

A

oncogene

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20
Q

RET - oncogene or tumor suppressor gene?

A

oncogene

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21
Q

RAS - oncogene or tumor suppressor gene?

A

oncogene

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22
Q

APC - oncogene or tumor suppressor gene?

A

tumor suppressor gene

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23
Q

Rb - oncogene or tumor suppressor gene?

A

tumor suppressor gene

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24
Q

NF1 - oncogene or tumor suppressor gene?

A

tumor suppressor gene

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25
Q

NF2 - oncogene or tumor suppressor gene?

A

tumor suppressor gene

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26
Q

c-myc - oncogene or tumor suppressor gene?

A

oncogene

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27
Q

c-kit - oncogene or tumor suppressor gene?

A

oncogene

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28
Q

BRAF - oncogene or tumor suppressor gene?

A

oncogene

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29
Q

DCC - oncogene or tumor suppressor gene?

A

tumor suppressor gene

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30
Q

MEN1 - oncogene or tumor suppressor gene?

A

tumor suppressor gene

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31
Q

DPC4/SMAD4 - oncogene or tumor suppressor gene?

A

tumor suppressor gene

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32
Q

BRCA1/BRCA2 - oncogene or tumor suppressor gene?

A

tumor suppressor gene

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33
Q

WT1/WT2 - oncogene or tumor suppressor gene?

A

tumor suppressor gene

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34
Q

VHL - oncogene or tumor suppressor gene?

A

tumor suppressor gene

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35
Q

L-myc - oncogene or tumor suppressor gene?

A

oncogene

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36
Q

N-myc - oncogene or tumor suppressor gene?

37
Q

p16 - oncogene or tumor suppressor gene?

A

tumor suppressor gene

38
Q

p53 - oncogene or tumor suppressor gene?

A

tumor suppressor gene

39
Q

PTEN - oncogene or tumor suppressor gene?

A

tumor suppressor gene

40
Q

BCL2 - oncogene or tumor suppressor gene?

41
Q

TSC1 - oncogene or tumor suppressor gene?

A

tumor suppressor gene

42
Q

TSC2 - oncogene or tumor suppressor gene?

A

tumor suppressor gene

43
Q

HER2/neu (c-erbB2) - oncogene or tumor suppressor gene?

44
Q

BCR-ABL - product

A

Tyrosine kinase

45
Q

BCR-ABL - associated tumor

46
Q

BRAF - product

A

serine/threonine kinase

47
Q

BRAF - associated tumor

A

Melanoma, non-Hodgkin lymphoma

48
Q

BCL-2 - associated tumor

A

follicular and undifferentiated lymphomas

49
Q

BCL-2 - product

A

antiapoptotic molecule (inhibits apoptosis)

50
Q

RET - product

A

tyrosine kinase

51
Q

RET - associated tumor

A

MEN2A and MEN2B, medullary thyroid cancer, thyroid papillary carcinoma

52
Q

RAS - product

53
Q

RAS - associated tumor

A

colon cancer, lung cancer, pancreatic cancer

54
Q

c-kit - product

A

cytokine receptor

55
Q

c-kit - associated tumor

A

gastrointestinal stromal tumor (GIST)

56
Q

c-myc - products

A

Transcription factor

57
Q

c-myc - associated tumor

A

Burkitt lymphoma

58
Q

L-myc - gene product

A

Transcription factor

59
Q

L-myc - associated tumor

A

Lung tumor

60
Q

N-myc - gene product

A

Transcription factor

61
Q

N-myc - associated tumor

A

neuroblastoma

62
Q

HER2/neu (c-erbB2) - product

A

Tyrosine kinase

63
Q

HER2/neu (c-erbB2) - associated tumor

A

Breast, gastric carcinomas

64
Q

APC - associated tumor

A

Colorectal cancer (associated with FAP)

65
Q

BRCA1/2 - associated tumor

A

breast and ovarian cancer

66
Q

BRCA1/2 - product

A

gene repair protein

67
Q

DCC - associated tumor

A

colon cancer

68
Q

DPC4/SMAD4 - associated tumor

A

pancreatic cancer

69
Q

MEN1 - product

70
Q

MEN1 - associated tumor

71
Q

WT1/WT2 - associated tumor

A

Wilms tumor (neuroblastoma)

72
Q

VHL product

A

HIF1a inhibitor

73
Q

VHL - associated tumor

A

VHL disease

renal cell carcinoma

74
Q

TSC1 - product

A

Hamartin protein

75
Q

TSC1 - associated tumor

A

tuberous sclerosis

76
Q

TSC2 - product

A

Tuberin protein

77
Q

TSC2 - associated tumor

A

tuberous sclerosis

78
Q

Rb - product

A

inhibits E2F –> blocks G1 to S phase

79
Q

PTEN - associated tumor

A
  1. breast
  2. prostate
  3. endometrial
80
Q

Rb - associated tumor

A
  1. Retinoblastoma

2. osteosracoma

81
Q

NF1 - associated tumor

A

Neurofibromatosis type 1

82
Q

NF2 - associated tumor

A

Neurofibromatosis type 2

83
Q

NF2 - product

A

Merlin (schwannomin protein)

84
Q

NF1 - product

A

Ras GTPase activating protein (neurofibromin)

85
Q

p16 - product

A

Cyclin-dependent kinase inhibitor 2A

86
Q

p16 - associated tumor

87
Q

p53 - product

A

Transcription factor for p21–> blocks G1 to S phase

88
Q

p53 - associated tumor

A
  1. Most human cancers

2. Li-Fraumeni syndrome

Pathology FA (4 decks)

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