Neoplasm Flashcards
What is neoplasia?
A new growth that occurs by proliferation of cells
What is neoplasm
The new growth.
Abnormal mass of cell which grows in an uncoordinated manner with the cells of the bodyand continues to persist after the removal of the stimulus
What are the features of neoplasm?
Purposeless
Abnormal mass
Preys on the host
Autonomous
Neoplasms are common in cells with high …………. and are not found in ……… cells
Proliferating capacity( labile cells)
Stable cells , mature neurons and cardiac myocyte.
What are the transformed cells
Cells formed by the neoplasm
What are cells of origin?
What is the structure of the neoplasm
Parenchyma cells from the cell of origin
Connective tissue from stroma of the host
Nomenclature of neoplasm are based on ………….
Histogenesis ( cell of origin)
Biological nature
Descriptive modifier
Eponymous
The 5 classes of bening tumour include:
Histogenic classification e.g chondroma
Characteristics classification e.g papilloma, adenoma.
Teratoma
Hamartoma
Choristoma
Nomenclature of bening tumour
Parenchymal- carcinoma
Mesenchymal - sarcoma
The growth factor gene that are implicated in oncogenesis include
C sis codes for PDGF
hst 1 and hst2 that encodes FGF
The GF receptors are integral membrane protein with ……………. activity
Tyrosine kinase activity
The receptors that are implicated in oncogenesis include
C erb B1 B2 B3
Csf 1 receptor fms ret
Mutation of GAP is seen in ….
Neurofibromatosis type 1
The implicated GAP is neurofibromin 1
In group 2 clinical features of carcinoma a bronchogenic ca results in other clinical features like
Pan Coast tumour pleural effusion + shoulder pain distributed to ulnar due to its effect on T1 and T2
Horners tumour: cervical sympathetic ganglion
Pericardial effusion
SVC syndrome : obstruction of SVC due to invasion of chest wall
