Cell Injury

Question 1

What forms the cornerstone of diagnosis of a diseases?

Answer 1

Morphological changes

Question 2

The homeostasis of a cell Is governed by………..

Answer 2

1.It’s own metabolic, differentiation and specialisation process
2.Constraints by other cells
3.Availability of metabolic substrate

Question 3

A localised area of ischaemia necrosis is called ………

Answer 3

Infarct

Question 4

List the two types of death receptors on a cell

Answer 4

Type 1 TNF
Fas (CD95)

Question 5

Phagocytosis of apoptotic cell us called

Answer 5

Efferocytosis

Question 6

What happens to the macrophages that phagocytize apoptotic cell

Answer 6

They are inhibited from releasing pro-inflammatory cytokines in order to limit inflammation

Question 7

Apoptotic cells are coated with………. and complement proteins especially…………

Answer 7

Antibodies
C1q

Question 8

What is necroptosis
Ferroptosis
Pyroptosis

Question 9

List the examples of ROS

Answer 9

Superoxide anion
H2O2
Peroxynitrite( ONOO)
Nitrite
Nitric oxide(HNO2)
Hydroxyl radical

Question 10

What is oxidative stress

Answer 10

Increases ROS or reduced scavengers for ROS which leads to accumulation

Question 11

Transition metals are stored in …….

Answer 11

Transferrin
Ferritin
Ceruloplasmin
Lactoferin

Question 12

What shows the oxidative state of a cell

Answer 12

The ratio of reduced to oxidised glutathione