Immunopathology

Question 1

The primary lymphoid organs are ………, ………….

Answer 1

Thymus
Bone marrow

Question 2

PAMPs are usually what molecule?

Answer 2

Peptidoglycan or
Lipopolysaccharide

Question 3

What is the MHC molecule and what is another name for it

Answer 3

It is a molecule that presents peptide fragments of protein antigen fir recognition by specific T cells.
Human leukocyte antigen ( H LA) It evokes tissue rejection during orhan transplant

Question 4

Class 1 MHC are expressed on which cells …………….

Answer 4

Nucleated cells
Platelets

Question 5

Describe the MHC class 1

Answer 5

Hetorodimer consisting of a
Polymorphic a or heavy chain(42KD) attached to a non polymorphic protein B2 microglobulin

Question 6

The MHC consist of three domains and are coded for by three genes

Answer 6

HLA 1, 2,3
a 1 23

Question 7

Lymphocyte constitute …………. % of WBC

Answer 7

20-40%

Question 8

The peptide antigens presented to MHC are degraded in …………..

Answer 8

Proteasome

Question 9

What is the class I MHC restricted cell

Answer 9

CD8 + lymphocyte

Question 10

Class MHC are encoded in which gene
With which sub regions

Answer 10

HLA D

D P
D Q
D R

Question 11

The MHC II ia an heterodimer consisting of 2 polymorphic chain which are designated……… ……..
With 2 domains respectively

Answer 11

a and B chain
a1 and a2 domain
B1 B2 domain

Question 12

The principal co stimulator ( signal II) expressed by APC Is

Answer 12

B7 which bonds CD28 receptor

Question 13

The essence of signal II is to ensure

Answer 13

That adaptive immune response is induced by microbes not harmless substances

Question 14

The cytokine involved in adaptive immunity include

Answer 14

IL2
IFNY by Th1
IL4 by Th2 stimulate Bcells into IgE producing plasma cells
IL5 by Th2 stimulate production of eosinophil at site of production and activation at site of immune response
IL17

Question 15

Activation of Th2 leads to ………. pathway activation of macrophages

Answer 15

Alternative pathway activation of macrophages

Question 16

Activation of Th2 leads to ………. pathway activation of macrophages

Answer 16

Alternative pathway activation of macrophages

Question 17

Th1 pathway of macrophages is ……… pathway

Answer 17

Classical pathway

Question 18

Th17 cells secrets IL17 which does …….

Answer 18

Recruit neutrophils and monocytes which destroy Extracellular bacteria

Question 19

The functions of helper T cells are mediated by a combination of CD40 ligands and ……….

Answer 19

Cytokines