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Board Review - B - Pathology > Neoplasia II > Flashcards

Neoplasia II Flashcards

1
Q

oncogenes

A 
BCR-ABL
Bcl2
BRAF
c-kit
c-myc
HER2/neu
L-myc
N-myc
RAS
RET
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2
Q

BCR-ABL

A

oncogene - tyrosine kinase

CML and ALL

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3
Q

Bcl2

A

oncogene - antioptotic

follicular and undifferentiated lymphomas

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4
Q

BRAF

A

oncogene - serine/threonine kinase

melanoma
non-hodgkin lymphoma

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5
Q

c-kit

A

oncogene - cytokine receptor

GI stromal tumor - GIST

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6
Q

Her2/neu

A

aka - c-erbB2
oncogene - tyrosine kinase

breast, ovarian, gastric carcinoma

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7
Q

L-myc

A

oncogene - transcription factor

lung tumor

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8
Q

N-myc

A

oncogene - transcription factor

neuroblastoma

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9
Q

RAS

A

oncogene - GTPase

colon, lung, pancreatic cancer

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10
Q

RET

A

oncogene - tyroskine kinase

MEN 2A and 2B
medullary thyroid carcinoma

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11
Q

APC

A

tumor suppressor

colorectal cancer

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12
Q

BRCA1 and BRCA2

A

tumor suppressor
-DNA repair protein

breast and ovarian cancer

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13
Q

DCC

A

tumor suppressor
-DCC

colon cancer

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14
Q

DPC4/SMAD4

A

tumor suppressor
-DPC

pancreatic cancer

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15
Q

MEN1

A

tumor suppressor
-menin

MEN1

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16
Q

NF1

A

tumor suppressor

Ras GTPase - activating protein

17
Q

NF2

A

tumor suppressor

merlin (schwannomin) protein

18
Q

p16

A

tumor suppressor
-cyclin dependent kinase inhibitor 2A

melanoma

19
Q

p53

A

tumor suppressor
-transcription factor for p21 - block G1>S

most cancers
li fraumeni

20
Q

PTEN

A

tumor suppressor

breast, prostate, endometrial cancer

21
Q

Rb

A

tumor suppressor
-inhibit E2F - block G1 > S

retinoblastoma
osteosarcoma

22
Q

TSC1

A

tumor suppressor
-hamartin protein

tuberous sclerosis

23
Q

TSC2

A

tumor suppressor
-tuberin protein

tuberous sclerosis

24
Q

VHL

A

tumor suppressor
-inhibit HIF-1

VHL disease
renal cell carcinoma

25
Q

WT1/WT2

A

tumor suppressor

wilms tumor - nephroblastoma

26
Q

tumor markers

A

to monitor recurrence

27
Q

alk phos

A

met to bone or liver
paget diseas of bone
seminoma

28
Q

a-fetoprotein

A

normally made by fetus
-elevated in pregnancy

high level - neural tube and abdominal wall defect
low level - down syndrome

29
Q

B-hCG

A

hydatidiform mole
choriocarcinoma - trophoblastic disease

produced by placenta

30
Q

CA15-3

A

breast ca

31
Q

CA27-29

A

breast ca

32
Q

CA 19-9

A

pancreatic adenocarcinoma

33
Q

CA 125

A

ovarian cancer

34
Q

calcitonin

A

medullary thyroid carcinoma

35
Q

CEA

A

70% colorectal and pancreatic cancer

also - gastric, breast, medullary thyroid carcinoma

36
Q

chromogranin

A

neuroendocrine tumor

carcinoid

37
Q

PSA

A

prostate cancer

can be elevated in BPH and prostatitis

Board Review - B - Pathology (5 decks)

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