Neoplasia II

Question 1

oncogenes

Answer 1

BCR-ABL
Bcl2
BRAF
c-kit
c-myc
HER2/neu
L-myc
N-myc
RAS
RET

Question 2

BCR-ABL

Answer 2

oncogene - tyrosine kinase

CML and ALL

Question 3

Bcl2

Answer 3

oncogene - antioptotic

follicular and undifferentiated lymphomas

Question 4

BRAF

Answer 4

oncogene - serine/threonine kinase

melanoma
non-hodgkin lymphoma

Question 5

c-kit

Answer 5

oncogene - cytokine receptor

GI stromal tumor - GIST

Question 6

Her2/neu

Answer 6

aka - c-erbB2
oncogene - tyrosine kinase

breast, ovarian, gastric carcinoma

Question 7

L-myc

Answer 7

oncogene - transcription factor

lung tumor

Question 8

N-myc

Answer 8

oncogene - transcription factor

neuroblastoma

Question 9

RAS

Answer 9

oncogene - GTPase

colon, lung, pancreatic cancer

Question 10

RET

Answer 10

oncogene - tyroskine kinase

MEN 2A and 2B
medullary thyroid carcinoma

Question 11

APC

Answer 11

tumor suppressor

colorectal cancer

Question 12

BRCA1 and BRCA2

Answer 12

tumor suppressor
-DNA repair protein

breast and ovarian cancer

Question 13

DCC

Answer 13

tumor suppressor
-DCC

colon cancer

Question 14

DPC4/SMAD4

Answer 14

tumor suppressor
-DPC

pancreatic cancer

Question 15

MEN1

Answer 15

tumor suppressor
-menin

MEN1

Question 16

NF1

Answer 16

tumor suppressor

Ras GTPase - activating protein

Question 17

NF2

Answer 17

tumor suppressor

merlin (schwannomin) protein

Question 18

p16

Answer 18

tumor suppressor
-cyclin dependent kinase inhibitor 2A

melanoma

Question 19

p53

Answer 19

tumor suppressor
-transcription factor for p21 - block G1>S

most cancers
li fraumeni

Question 20

PTEN

Answer 20

tumor suppressor

breast, prostate, endometrial cancer

Question 21

Rb

Answer 21

tumor suppressor
-inhibit E2F - block G1 > S

retinoblastoma
osteosarcoma

Question 22

TSC1

Answer 22

tumor suppressor
-hamartin protein

tuberous sclerosis

Question 23

TSC2

Answer 23

tumor suppressor
-tuberin protein

tuberous sclerosis

Question 24

VHL

Answer 24

tumor suppressor
-inhibit HIF-1

VHL disease
renal cell carcinoma

Question 25

WT1/WT2

Answer 25

tumor suppressor

wilms tumor - nephroblastoma

Question 26

tumor markers

Answer 26

to monitor recurrence

Question 27

alk phos

Answer 27

met to bone or liver
paget diseas of bone
seminoma

Question 28

a-fetoprotein

Answer 28

normally made by fetus
-elevated in pregnancy

high level - neural tube and abdominal wall defect
low level - down syndrome

Question 29

B-hCG

Answer 29

hydatidiform mole
choriocarcinoma - trophoblastic disease

produced by placenta

Question 30

CA15-3

Answer 30

breast ca

Question 31

CA27-29

Answer 31

breast ca

Question 32

CA 19-9

Answer 32

pancreatic adenocarcinoma

Question 33

CA 125

Answer 33

ovarian cancer

Question 34

calcitonin

Answer 34

medullary thyroid carcinoma

Question 35

CEA

Answer 35

70% colorectal and pancreatic cancer

also - gastric, breast, medullary thyroid carcinoma

Question 36

chromogranin

Answer 36

neuroendocrine tumor

carcinoid

Question 37

PSA

Answer 37

prostate cancer

can be elevated in BPH and prostatitis