Inflammation II Flashcards
phases of wound healing
1 inflammation - up to 3 days - neutro, platelet, macros
2 - proliferative - day 3 to week - granulation tissue
-wound contraction - myofibroblasts
3 remodeling - week to months - type III collagen - replace type I
-fibroblasts
granulomatous diseases
Th1 cells - secrete IFN-gamma
-activate macros
TNF-a - induce maintain granuloma
anti-TNF drugs
breakdown of granuloma - TB reactivation
always test for TB with anti-TNF therapy
granuloma diseases
cat scratch disease berylliosis churg strauss crohns - non-caseating foreign body francisella fungal wegeners listeria monocytogenes leprosy TB syphilis - tertiary sarcoid - non-caseating schistosomiasis
exudate
cellular
protein
high specific gravity
with lymph obstruction, inflammation, malignancy
transudate
hypocellular
low specific gravity
hydrostatic P, oncotic P, Na retention
ESR
product of inflammation - coat RBC - cause aggregation
dense RBC - fall at faster rate
faster with anemia, infection, inflammation, cancer, pregnancy, autoimmune
slower with sickle cell, polycythemia, HF, microcytosis, hypofibrinogenemia
amyloidosis
aggregation proteins into B-pleated sheets
AL amyloid
light chains
multi myeloma
AA amyloid
chronic inflammation
-RA, IBD, spondyloarthropathy
fibrils - serum amyloid A
dialysis amyloid
B2 microglobulin wth ESRD
presentation - carpal tunnel
heritable amyloid
transthyretin mutation
age related amyloidosis
deposition of wild type transthyretin in myocardium
slow progression
alzheimer disease
deposits of B-amyloid - cleaved from APP - amyloid precursor protein
islet amyloid polypeptide
seen in DM II - deposits of amylin in pancreati islets
