Inflammation II Flashcards
phases of wound healing
1 inflammation - up to 3 days - neutro, platelet, macros
2 - proliferative - day 3 to week - granulation tissue
-wound contraction - myofibroblasts
3 remodeling - week to months - type III collagen - replace type I
-fibroblasts
granulomatous diseases
Th1 cells - secrete IFN-gamma
-activate macros
TNF-a - induce maintain granuloma
anti-TNF drugs
breakdown of granuloma - TB reactivation
always test for TB with anti-TNF therapy
granuloma diseases
cat scratch disease berylliosis churg strauss crohns - non-caseating foreign body francisella fungal wegeners listeria monocytogenes leprosy TB syphilis - tertiary sarcoid - non-caseating schistosomiasis
exudate
cellular
protein
high specific gravity
with lymph obstruction, inflammation, malignancy
transudate
hypocellular
low specific gravity
hydrostatic P, oncotic P, Na retention
ESR
product of inflammation - coat RBC - cause aggregation
dense RBC - fall at faster rate
faster with anemia, infection, inflammation, cancer, pregnancy, autoimmune
slower with sickle cell, polycythemia, HF, microcytosis, hypofibrinogenemia
amyloidosis
aggregation proteins into B-pleated sheets
AL amyloid
light chains
multi myeloma
AA amyloid
chronic inflammation
-RA, IBD, spondyloarthropathy
fibrils - serum amyloid A
dialysis amyloid
B2 microglobulin wth ESRD
presentation - carpal tunnel
heritable amyloid
transthyretin mutation
age related amyloidosis
deposition of wild type transthyretin in myocardium
slow progression
alzheimer disease
deposits of B-amyloid - cleaved from APP - amyloid precursor protein
islet amyloid polypeptide
seen in DM II - deposits of amylin in pancreati islets
congo red stain
amyloid
apple green birefringement
lipofuscin
yellow brown
wear and tear pigment
with normal aging
oxidation and polymerization of autophagocytosed organellar membranes
deposit in heart, colon, liver, kidney, eye, other organs
