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Board Review - B - Pathology > Neoplasia I > Flashcards

Neoplasia I Flashcards

1
Q

dysplasia

A

proliferation cells

loss size shape and orientation

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2
Q

CIS

A

not invaded BM

nuclear:cytoplasm ratio increased

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3
Q

invasive carcinoma

A

invaded BM
-metalloproteinase

loss E-cadherin

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4
Q

P-glycoprotein

A

MDR1
-seen in adrenal cell carcinoma and other cancers

used to pump out toxins
-including chemotherapy agent

mechanism of resistance to chemo drug

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5
Q

reversible

A

hyperplasia
metaplasia
dysplasia

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6
Q

irreversible

A

anaplasia
neoplasia
desmoplasia

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7
Q

anaplasia

A

loss structural differentiation and function of cells

resemble primitive cells

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8
Q

desmoplasia

A

fibrous tissue formation

-response to neoplasm

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9
Q

grade of tumor

A

differentiation

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10
Q

stage of tumor

A

degree of spread
T - tumor
N - nodes
M - mets

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11
Q

important for prognosis

A

stage

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12
Q

carcinoma

A

epithelial origin

spread lymphatics

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13
Q

sarcoma

A

mesenechymal origin

spread hematogenous

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14
Q

carcinoma and sarcoma

A

malignant

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15
Q

hamartoma

A

disorganized overgrowth tissue native location

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16
Q

choristoma

A

normal tissue in foreign location

ex/ gastric tissue in meckel diverticulum

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17
Q

hemangioma

A

blood vessel B9

18
Q

rhabdomyoma

A

striated muscle B9

19
Q

fibroma

20
Q

osteoma

21
Q

cachexia

A

TNF a

and IFN-gamma, IL1, IL6

22
Q

acanthosis nigricans

A

with GI neoplasm

or insulin resistance

23
Q

barret esophagus

A

precursor esophageal adenocarcinoma

24
Q

ulcerative colitis

A

predispose colon adenocarcinoma

25
Q

cirrhosis

A

predispose hepatocellular carcinoma

26
Q

actinic keratosis

A

precursor SCC of skin

27
Q

dysplastic nevus

A

precursor malignant melanoma

28
Q

multiple seborrheic keratoses

A

precursor GI, breast, lung, lymph malignancy

29
Q

paget disease of bone

A

predispose to secondary osteosarcoma and fibrosarcoma

30
Q

plummer vinson syndrome

A

predispose to SCC of esophagus

31
Q

tuberous sclerosis

A

multiple hamartoma - B9

32
Q

xeroderma pigmentosa

A

predispose to SCC, basal cell carcinoma, melanoma

33
Q

AIDS

A

predispose aggressive lymphoma - non-hodgkin

and kaposi sarcoma

34
Q

autoimmune disease

A

predispose lymphoma

35
Q

down syndrome

A

predispose ALL

36
Q

immunodeficiency

A

predispose lymphoma, melanoma, renal cell carcinoma

37
Q

li fraumeni syndrome

A

p53 mutation

predispose to lots o cancers

38
Q

radiation exposure

A

risk for leukemia, sarcoma, papillary thyroid cancer, breast cancer

39
Q

oncogenes

A

need damage only 1 allele

40
Q

tumor suppressor genes

A

need damage both alleles

Board Review - B - Pathology (5 decks)

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