Neoplasia Flashcards
What is a neoplasm?
This is an abnormal growth of cells which persists even when the initial stimulus has been removed.
What is a malignant neoplasm?
A neoplasm which has the capability to invade surrounding tissues and spread to distant sites.
What is a tumour?
A physically detectable lump or swelling.
What is another word for malignant neoplasm?
Cancer
What is metastasis?
A malignant neoplasm which has spread from its original site to a new non-continuous site.
What is dysplasia? Is this neoplastic?
This is cells which show disordered tissue organisation. It is not neoplastic because it is reversible.
How will a benign neoplasm look?
It will push and squash the surrounding tissue as it grows.
What will be seen when a mallignant neoplasm is present in tissues?
This will have an irregular border as it invades tissue and ulceration and necrosis occur when on a surface.
Define anaplastic
These are cells which have no resemblance to the original tissue
What changes are seen to nuclei as neoplasms progress?
The nuclei increase in size, and there is a greater nucleus to cytoplasm ratio.
What is pleomorphism?
This is where a tissue has cells with a wide variety of sizes and shapes.
What is hyperchromasia?
Increased nucleus staining.
How can we define dysplasia which has worsened to a stage where it is no longer reversible?
Carcinoma in situ.
What type of dell population is a neoplasm?
Monoclonal
What is cancer progression?
This is characterised by the cell suffering further mutations.
