Neoplasia

Question 1

Apoptosis regulator genes

Answer 1

The cell is Bad and goes to apoptosis
Bcl2: it PREVENTS apoptosis, overexpression associated with lymphomas
Bax 
Bad
Bcl-xs 
Bid

Question 2

Bcr-abl

Answer 2

It’s is an oncogene, tyrosine kinase activity, that is associated with CmL and ALL

Question 3

What is an oncogene, how many alleles have to affect to produce cancer?

Answer 3

It is a gain of function of a gene that produces cancer, only needs to affect one allele

Question 4

Her2neu associated neoplasms

Answer 4

Breast, ovarian, gastric carcinomas.

Question 5

What is RAS mutation, what neoplasms are associated with it

Answer 5

It is an oncogene and is associated with colon, lung, pancreas cancer

Question 6

What kind of gene is Brca1/2?associated neoplasms?

Answer 6

Tumor suppressor gene, breast and ovarian CA

Question 7

Tumor suppressor genes and their mutations

Answer 7

What kind of genes are these?
P53: it’s mutation is associated with li-fraumeni sd
Retinoblastoma: it’s mutation is associated with retinoblastoma and osteosarcoma